Genetically Engineered Phage-Templated MnO2 Nanowires: Synthesis and Their Application in Electrochemical Glucose Biosensor Operated at Neutral pH Condition

doi:10.1021/acsami.6b03266

QIBEBT-IR > 生物传感技术团队（过去）

	Genetically Engineered Phage-Templated MnO2 Nanowires: Synthesis and Their Application in Electrochemical Glucose Biosensor Operated at Neutral pH Condition
	Han, Lei1,2,3 ; Shao, Changxu 1,2,3; Liang, Bo3 ; Liu, Aihua 1,2
	2016-06-08
发表期刊	ACS APPLIED MATERIALS & INTERFACES
卷号	8 期号:22 页码:13768-13776
摘要	To conveniently obtain one-dimensional MnO2 nanowires (NWs) with controlled structure and unique properties for electron transfer, the genetically engineered M13 phages were used as templates for precise nucleation and growth of MnO2 crystals in filamentous phage scaffolds, via the spontaneous oxidation of Mn2+ in alkaline solution. It was found that the morphology of NWs could be tailored by the surface charge of M13 mutants. MnO2 crystals were uniformly distributed on the surface of negatively charged tetraglutamate-fused phage (M13-E4), significantly different from irregular MnO2 agglomeration on the weakly negatively charged wild-type phage and positively charged tetraarginine-fused phage. The as-synthesized M13-E4@MnO2 NWs could catalyze the electro-oxidation of H2O2 at neutral pH. To demonstrate the superiority of the electrocatalytic activity in the solution containing plenty of chloride ions at neutral pH, both glucose oxidase and as-prepared MnO2 NWs were used for fabricating the glucose biosensor. The proposed biosensor showed a wide linear range (5 mu M to 2 mM glucose), a low limit of detection of 1.8 mu M glucose (S/N = 3), good interassay and intra-assay reproducibility and satisfactory storage stability. Due to the superiorities of synthesis and electrochemical performance, the as-prepared MnO2 NWs are promising for applications in electrocatalysis, electrochemical sensor, and supercapacitor.
文章类型	Article
关键词	Mno2 Nanowires Biotemplate Synthesis Phage Display Electrochemical Glucose Biosensor Neutral Ph
WOS标题词	Science & Technology ; Technology
DOI	10.1021/acsami.6b03266
关键词[WOS]	HYDROGEN-PEROXIDE ; ALPHA-MNO2 NANOTUBES ; BETA-MNO2 NANORODS ; ION BATTERIES ; VIRUS ; SENSOR ; NANOSTRUCTURES ; NANOPARTICLES ; NANOCOMPOSITE ; ELECTRODE
收录类别	SCI
语种	英语
WOS研究方向	Science & Technology - Other Topics ; Materials Science
项目资助者	National Natural Science Foundation of China(21275152 ; 21475144)
WOS类目	Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS记录号	WOS:000377642100013
引用统计
文献类型	期刊论文
条目标识符	http://ir.qibebt.ac.cn/handle/337004/8323
专题	生物传感技术团队（过去）
作者单位	1.Qingdao Univ, Inst Biosensing, Qingdao 266071, Peoples R China 2.Qingdao Univ, Coll Chem & Chem Engn, Qingdao 266071, Peoples R China 3.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Lab Biosensing, 189 Songling Rd, Qingdao 266101, Peoples R China 4.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Han, Lei,Shao, Changxu,Liang, Bo,et al. Genetically Engineered Phage-Templated MnO2 Nanowires: Synthesis and Their Application in Electrochemical Glucose Biosensor Operated at Neutral pH Condition[J]. ACS APPLIED MATERIALS & INTERFACES,2016,8(22):13768-13776.
APA	Han, Lei,Shao, Changxu,Liang, Bo,&Liu, Aihua.(2016).Genetically Engineered Phage-Templated MnO2 Nanowires: Synthesis and Their Application in Electrochemical Glucose Biosensor Operated at Neutral pH Condition.ACS APPLIED MATERIALS & INTERFACES,8(22),13768-13776.
MLA	Han, Lei,et al."Genetically Engineered Phage-Templated MnO2 Nanowires: Synthesis and Their Application in Electrochemical Glucose Biosensor Operated at Neutral pH Condition".ACS APPLIED MATERIALS & INTERFACES 8.22(2016):13768-13776.