| Microbiota-based Signature of Gingivitis Treatments: A Randomized Study | |
Huang, Shi1,2,7,8; Li, Zhen3; He, Tao4 ; Bo, Cunpei1,2; Chang, Jinlan5; Li, Lin5; He, Yanyan5; Liu, Jiquan6; Charbonneau, Duane4; Li, Rui6; Xu, Jian1,2
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| 2016-04-20 | |
| 发表期刊 | SCIENTIFIC REPORTS
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| 卷号 | 6 |
| 摘要 | Plaque-induced gingivitis can be alleviated by various treatment regimens. To probe the impacts of various anti-gingivitis treatments on plaque microflora, here a double blinded, randomized controlled trial of 91 adults with moderate gingivitis was designed with two anti-gingivitis regimens: the brush-alone treatment and the brush-plus-rinse treatment. In the later group, more reduction in both Plaque Index (TMQHI) and Gingival Index (mean MGI) at Day 3, Day 11 and Day 27 was evident, and more dramatic changes were found between baseline and other time points for both supragingival plaque microbiota structure and salivary metabonomic profiles. A comparison of plaque microbiota changes was also performed between these two treatments and a third dataset where 50 subjects received regimen of dental scaling. Only Actinobaculum, TM7 and Leptotrichia were consistently reduced by all the three treatments, whereas the different microbial signatures of the three treatments during gingivitis relieve indicate distinct mechanisms of action. Our study suggests that microbiota based signatures can serve as a valuable approach for understanding and potentially comparing the modes of action for clinical treatments and oral-care products in the future. |
| 文章类型 | Article |
| WOS标题词 | Science & Technology |
| DOI | 10.1038/srep24705 |
| 关键词[WOS] | CETYLPYRIDINIUM CHLORIDE MOUTHRINSES ; CHAIN FATTY-ACIDS ; PERIODONTAL-DISEASE ; ANTIMICROBIAL EFFICACY ; ORAL MICROBIOTA ; DENTAL-CARIES ; REVEALS ; CHLORHEXIDINE ; BACTERIA ; PLAQUE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS研究方向 | Science & Technology - Other Topics |
| 项目资助者 | National Natural Science Foundation of China(31400089 ; Procter & Gamble Company, Cincinnati, OH ; 81430011) |
| WOS类目 | Multidisciplinary Sciences |
| WOS记录号 | WOS:000374378000001 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qibebt.ac.cn/handle/337004/8265 |
| 专题 | 单细胞中心组群 |
| 作者单位 | 1.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Single Cell Ctr, Qingdao 266101, Shandong, Peoples R China 2.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Shandong Key Lab Energy Genet, Qingdao 266101, Shandong, Peoples R China 3.Beijing Union Med Coll Hosp, Dept Stomatol, Beijing 100730, Peoples R China 4.Procter & Gamble Mason Business Int, Cincinnati, OH 45040 USA 5.Procter & Gamble Innovat Ctr, Beijing 101312, Peoples R China 6.Procter & Gamble Int Operat SA SG Branch, Singapore 138547, Singapore 7.Sinodanish Ctr Educ & Res, Beijing 100190, Peoples R China 8.Univ Chinese Acad Sci, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Shi,Li, Zhen,He, Tao,et al. Microbiota-based Signature of Gingivitis Treatments: A Randomized Study[J]. SCIENTIFIC REPORTS,2016,6. |
| APA | Huang, Shi.,Li, Zhen.,He, Tao.,Bo, Cunpei.,Chang, Jinlan.,...&Xu, Jian.(2016).Microbiota-based Signature of Gingivitis Treatments: A Randomized Study.SCIENTIFIC REPORTS,6. |
| MLA | Huang, Shi,et al."Microbiota-based Signature of Gingivitis Treatments: A Randomized Study".SCIENTIFIC REPORTS 6(2016). |
| 条目包含的文件 | 条目无相关文件。 | |||||
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