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	Different Impacts of Short-Chain Fatty Acids on Saturated and Polyunsaturated Fatty Acid Biosynthesis in Aurantiochytrium sp
	Song, X.; Tan, Y.; Liu, Y.; Zhang, J.; Liu, G.; Feng, Y.; & Cui, Q.
	2013
发表期刊	SD116. J Agric Food Chem
卷号	61期号:41页码:9876-9881
摘要	Aurantiochytrium is an important docosahexaenoic acid (DHA) producer containing two kinds of fatty acid synthesis pathways, that is, the fatty acid synthase pathway (FAS) for saturated fatty acid synthesis and the polyketide synthase pathway (PKS) for polyunsaturated fatty acid synthesis. To understand the regulation mechanism between the two pathways, the impacts of six short-chain fatty acids on the fatty acid synthesis of Aurantiochytrium sp. SD116 were studied. All short-chain fatty acids showed little effect on the cell growth, but some of them significantly affected lipid accumulation and fatty acid composition. Pentanoic acid and isovaleric acid greatly inhibited the synthesis of saturated fatty acids, whereas the polyunsaturated fatty acid synthesis was not affected. Analysis of malic enzyme activity, which supplied NADPH for saturated fatty acids biosynthesis, indicated that the two fatty acid synthesis pathways can utilize different substrates and possess independent sources of NADPH.
关键词	Aurantiochytrium Docosahexaenoic Acid Fatty Acid Synthase Malic Enzyme Polyketide Synthase
学科领域	代谢物组学
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.qibebt.ac.cn/handle/337004/1683
专题	代谢物组学研究组
推荐引用方式 GB/T 7714	Song, X.,Tan, Y.,Liu, Y.,et al. Different Impacts of Short-Chain Fatty Acids on Saturated and Polyunsaturated Fatty Acid Biosynthesis in Aurantiochytrium sp[J]. SD116. J Agric Food Chem,2013,61(41):9876-9881.
APA	Song, X..,Tan, Y..,Liu, Y..,Zhang, J..,Liu, G..,...&& Cui, Q..(2013).Different Impacts of Short-Chain Fatty Acids on Saturated and Polyunsaturated Fatty Acid Biosynthesis in Aurantiochytrium sp.SD116. J Agric Food Chem,61(41),9876-9881.
MLA	Song, X.,et al."Different Impacts of Short-Chain Fatty Acids on Saturated and Polyunsaturated Fatty Acid Biosynthesis in Aurantiochytrium sp".SD116. J Agric Food Chem 61.41(2013):9876-9881.

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