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Inducible cell lysis systems in microbial production of bio-based chemicals
Gao, Yongqiang1,3; Feng, Xinjun1,3; Xian, Mo1,2; Wang, Qi1,3; Zhao, Guang1,2
2013-08-01
Source PublicationAPPLIED MICROBIOLOGY AND BIOTECHNOLOGY
Volume97Issue:16Pages:7121-7129
AbstractThe release of products from microbial cells is an essential process for industrial scale production of bio-based chemicals. However, traditional methods of cell lysis, e.g., mechanical disruption, chemical solvent extraction, and immobilized enzyme degradation, account for a large share of the total production cost. Thus, an efficient cell lysis system is required to lower the cost. This review has focused on our current knowledge of two cell lysis systems, bacteriophage holin-endolysin system, and lipid enzyme hydrolysis system. These systems are controlled by conditionally inducible regulatory apparatus and applied in microbial production of fatty acids and polyhydroxyalkanoates. Moreover, toxin-antitoxin system is also suggested as alternative for its potential applications in cell lysis. Compared with traditional methods of cell disruption, the inducible cell lysis systems are more economically feasible and easier to control and show a promising perspective in industrial production of bio-based chemicals.
SubtypeReview
KeywordCell Lysis Systems Inducible Regulatory Apparatus Holin-endolysin System Lipid Enzyme System Toxin-antitoxin System
Subject Area生物基化学品
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1007/s00253-013-5100-x
WOS KeywordENGINEERED ESCHERICHIA-COLI ; BACILLUS-MEGATERIUM ; LACTOCOCCUS-LACTIS ; XYLOSE UTILIZATION ; OUTER MEMBRANES ; YEAST-CELLS ; FATTY-ACIDS ; LAMBDA-S ; PCC 6803 ; EXPRESSION
Indexed BySCI
Language英语
WOS Research AreaBiotechnology & Applied Microbiology
WOS SubjectBiotechnology & Applied Microbiology
WOS IDWOS:000322408100005
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qibebt.ac.cn/handle/337004/1660
Collection材料生物技术研究中心
Affiliation1.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao 266101, Peoples R China
2.Chinese Acad Sci, Key Lab Biobased Mat, Qingdao 266101, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Gao, Yongqiang,Feng, Xinjun,Xian, Mo,et al. Inducible cell lysis systems in microbial production of bio-based chemicals[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2013,97(16):7121-7129.
APA Gao, Yongqiang,Feng, Xinjun,Xian, Mo,Wang, Qi,&Zhao, Guang.(2013).Inducible cell lysis systems in microbial production of bio-based chemicals.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,97(16),7121-7129.
MLA Gao, Yongqiang,et al."Inducible cell lysis systems in microbial production of bio-based chemicals".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 97.16(2013):7121-7129.
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