Inducible cell lysis systems in microbial production of bio-based chemicals | |
Gao, Yongqiang1,3; Feng, Xinjun1,3; Xian, Mo1,2; Wang, Qi1,3; Zhao, Guang1,2 | |
2013-08-01 | |
发表期刊 | APPLIED MICROBIOLOGY AND BIOTECHNOLOGY |
卷号 | 97期号:16页码:7121-7129 |
摘要 | The release of products from microbial cells is an essential process for industrial scale production of bio-based chemicals. However, traditional methods of cell lysis, e.g., mechanical disruption, chemical solvent extraction, and immobilized enzyme degradation, account for a large share of the total production cost. Thus, an efficient cell lysis system is required to lower the cost. This review has focused on our current knowledge of two cell lysis systems, bacteriophage holin-endolysin system, and lipid enzyme hydrolysis system. These systems are controlled by conditionally inducible regulatory apparatus and applied in microbial production of fatty acids and polyhydroxyalkanoates. Moreover, toxin-antitoxin system is also suggested as alternative for its potential applications in cell lysis. Compared with traditional methods of cell disruption, the inducible cell lysis systems are more economically feasible and easier to control and show a promising perspective in industrial production of bio-based chemicals. |
文章类型 | Review |
关键词 | Cell Lysis Systems Inducible Regulatory Apparatus Holin-endolysin System Lipid Enzyme System Toxin-antitoxin System |
学科领域 | 生物基化学品 |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
DOI | 10.1007/s00253-013-5100-x |
关键词[WOS] | ENGINEERED ESCHERICHIA-COLI ; BACILLUS-MEGATERIUM ; LACTOCOCCUS-LACTIS ; XYLOSE UTILIZATION ; OUTER MEMBRANES ; YEAST-CELLS ; FATTY-ACIDS ; LAMBDA-S ; PCC 6803 ; EXPRESSION |
收录类别 | SCI |
语种 | 英语 |
WOS研究方向 | Biotechnology & Applied Microbiology |
WOS类目 | Biotechnology & Applied Microbiology |
WOS记录号 | WOS:000322408100005 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.qibebt.ac.cn/handle/337004/1660 |
专题 | 生物基材料组群 |
作者单位 | 1.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao 266101, Peoples R China 2.Chinese Acad Sci, Key Lab Biobased Mat, Qingdao 266101, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
推荐引用方式 GB/T 7714 | Gao, Yongqiang,Feng, Xinjun,Xian, Mo,et al. Inducible cell lysis systems in microbial production of bio-based chemicals[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2013,97(16):7121-7129. |
APA | Gao, Yongqiang,Feng, Xinjun,Xian, Mo,Wang, Qi,&Zhao, Guang.(2013).Inducible cell lysis systems in microbial production of bio-based chemicals.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,97(16),7121-7129. |
MLA | Gao, Yongqiang,et al."Inducible cell lysis systems in microbial production of bio-based chemicals".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 97.16(2013):7121-7129. |
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