An OR logic gate based on two molecular beacons

doi:10.1039/c2mb05477a

QIBEBT-IR > 先进有机功能材料研究组

An OR logic gate based on two molecular beacons

Guo, Jing; Yang, Renqiang

2012

发表期刊

MOLECULAR BIOSYSTEMS

卷号

8 期号:3 页码:927-930

摘要

Design of elementary molecular logic gates is the key and the fundamental of performing complicated Boolean calculations. Herein, we report a strategy for constructing a DNA-based OR gate by using the mechanism of sequence recognition and the principle of fluorescence resonance energy transfer (FRET). In this system, the gate is entirely composed of a single strand of DNA (A, B and C) and the inputs are the molecular beacon probes (MB1 and MB2). Changes in fluorescence intensity confirm the realization of the OR logic operation and electrophoresis experiments verify these results. Our successful application of DNA to perform the binary operation represents that DNA can serve as an efficient biomaterial for designing molecular logic gates and devices.

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; Design of elementary molecular logic gates is the key and the fundamental of performing complicated Boolean calculations. Herein, we report a strategy for constructing a DNA-based OR gate by using the mechanism of sequence recognition and the principle of fluorescence resonance energy transfer (FRET). In this system, the gate is entirely composed of a single strand of DNA (A, B and C) and the inputs are the molecular beacon probes (MB1 and MB2). Changes in fluorescence intensity confirm the realization of the OR logic operation and electrophoresis experiments verify these results. Our successful application of DNA to perform the binary operation represents that DNA can serve as an efficient biomaterial for designing molecular logic gates and devices.

文章类型

Article

学科领域

先进功能有机材料

WOS标题词

Science & Technology ; Life Sciences & Biomedicine

DOI

10.1039/c2mb05477a

关键词[WOS]

DNA LOGIC ; CHEMICAL INPUTS ; COMPUTATION ; CIRCUITS ; QUADRUPLEX ; PROTEINS ; BINDING ; DESIGN ; ENZYME ; PH

收录类别

SCI