The effect of different substitute groups and molecular weights of fucoidan on neuroprotective and anticomplement activity

doi:10.1016/j.ijbiomac.2018.02.109

QIBEBT-IR

	The effect of different substitute groups and molecular weights of fucoidan on neuroprotective and anticomplement activity
	Liu, Huaide 1; Wang, Jing 2,3,4; Zhang, Quanbin 2,3; Zhang, Hong 2,3
	2018-07-01
发表期刊	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN	0141-8130
卷号	113 页码:82-89
摘要	Ten fucoidan (FPS) derivatives were successfully synthesized, and their potential neuroprotective and anticomplement activities were investigated employing various established in vitro systems. The aim of the present study was to investigate the effects of different substitute groups and molecular weights of fucoidan on neuroprotective and anticomplement activities. All FPS derivatives possessed considerable neuroprotective and anticomplement activities and had stronger activities than FPS in certain tests. The in vitro results found that sulfated and benzoylated derivatives could reverse the decreased mitochondrial activity and decreased lactate dehydrogenase (LDH) and reactive oxygen species (ROS) release induced by 6-hydroxydopamine (6-OHDA, P < 0.01 or P < 0.001), which provides further evidence that sulfate and benzoylate groups could enhance the neuroprotective activity of fucoidan. In anticomplement experiments, all samples showed anticomplement activity in both systems; however, the sulfated and benzoylated derivatives showed better activity than fucoidan, with higher molecular weights showing the strongest activity. Available data suggested that substituted groups of fucoidan played an important role on neuroprotective and anticomplement activities. The mechanism of the influence of the neuroprotective and anticomplement activities of samples of the substituted groups was indicated. (C) 2018 Published by Elsevier B.V.
文章类型	Article
关键词	Fucoidan Derivatives Molecular Weights Substitute Group Neuroprotective Anticomplement
WOS标题词	Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
DOI	10.1016/j.ijbiomac.2018.02.109
关键词[WOS]	ACTIVITY IN-VITRO ; ANTIOXIDANT ACTIVITY ; LAMINARIA-JAPONICA ; PARKINSONS-DISEASE ; MITOCHONDRIAL DYSFUNCTION ; ANTI-COMPLEMENT ; BROWN SEAWEED ; DERIVATIVES ; POLYSACCHARIDES ; ACTIVATION
收录类别	SCI
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
项目资助者	Fujian the Science and Technology Project of Fujian Province(2017T3015) ; Science and Technology Project of Shandong Province(2016GSF115031) ; Open Fund Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology(0F2015N007) ; Youth Innovation Promotion Association of CAS(2016190) ; Natural Science Foundation of China (NSFC)(41406144) ; Natural Science Foundation of the Jiangsu Higher Education Institutions of China(15KJB170016)
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
WOS记录号	WOS:000432503100011
出版者	ELSEVIER SCIENCE BV
引用统计
文献类型	期刊论文
条目标识符	http://ir.qibebt.ac.cn/handle/337004/11452
专题	中国科学院青岛生物能源与过程研究所
通讯作者	Wang, Jing
作者单位	1.Nantong Univ, Sch Ocean, Sch Life Sci, Nantong, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, Nantong Branch, Nantong, Jiangsu, Peoples R China
推荐引用方式 GB/T 7714	Liu, Huaide,Wang, Jing,Zhang, Quanbin,et al. The effect of different substitute groups and molecular weights of fucoidan on neuroprotective and anticomplement activity[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2018,113:82-89.
APA	Liu, Huaide,Wang, Jing,Zhang, Quanbin,&Zhang, Hong.(2018).The effect of different substitute groups and molecular weights of fucoidan on neuroprotective and anticomplement activity.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,113,82-89.
MLA	Liu, Huaide,et al."The effect of different substitute groups and molecular weights of fucoidan on neuroprotective and anticomplement activity".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 113(2018):82-89.