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Biosynthesis of long chain hydroxyfatty acids from glucose by engineered Escherichia coli
Wang, Xiangwei1,2; Li, Lingling1,3; Zheng, Yanning1,2; Zou, Huibin1; Cao, Yujin1; Liu, Hui1; Liu, Wei1; Xian, Mo1
2012-06-01
发表期刊BIORESOURCE TECHNOLOGY
卷号114期号:114页码:561-566
摘要This study devised a pathway in Escherichia coli for direct production of long chain hydroxyfatty acids (HFAs) from glucose. This is first report on the biosynthesis of HFAs from renewable sugar, without the need of exogenous fatty acids. By employing thioesterases BTE and 'TesA to tailor the composition of free fatty acids (FFAs) and using fatty acid hydroxylase P450(BM3) to convert FFAs to HFAs, high-specificity production of C12 and C14 HFAs was achieved. By further knocking out the endogenous fadD gene of E. coli, an engineered strain capable of producing 117.0 mg/L HFAs was finally obtained, representing a high HFA production in shake flask. This study indicated an attractive metabolic strategy for the biosynthesis of HFAs directly from renewable carbohydrates resources. (C) 2012 Elsevier Ltd. All rights reserved.
文章类型Article
关键词Long Chain Hydroxyfatty Acid Escherichia Coli Thioesterase Fatty Acid Hydroxylase Fadd Knocking Out
学科领域生物基化学品
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Technology
DOI10.1016/j.biortech.2012.02.119
关键词[WOS]FATTY-ACIDS ; BACILLUS-MEGATERIUM ; MICROBIAL-PRODUCTION ; OLEIC-ACID ; MONOOXYGENASE ; HYDROXYLATION ; OMEGA ; BIOCATALYSIS ; THIOESTERASE ; RECOMBINANT
收录类别SCI
语种英语
WOS研究方向Agriculture ; Biotechnology & Applied Microbiology ; Energy & Fuels
WOS类目Agricultural Engineering ; Biotechnology & Applied Microbiology ; Energy & Fuels
WOS记录号WOS:000305035900079
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qibebt.ac.cn/handle/337004/1120
专题生物基材料组群
作者单位1.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao 266101, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
3.Sichuan Agr Univ, Coll Food Sci, Yaan 625014, Peoples R China
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GB/T 7714
Wang, Xiangwei,Li, Lingling,Zheng, Yanning,et al. Biosynthesis of long chain hydroxyfatty acids from glucose by engineered Escherichia coli[J]. BIORESOURCE TECHNOLOGY,2012,114(114):561-566.
APA Wang, Xiangwei.,Li, Lingling.,Zheng, Yanning.,Zou, Huibin.,Cao, Yujin.,...&Xian, Mo.(2012).Biosynthesis of long chain hydroxyfatty acids from glucose by engineered Escherichia coli.BIORESOURCE TECHNOLOGY,114(114),561-566.
MLA Wang, Xiangwei,et al."Biosynthesis of long chain hydroxyfatty acids from glucose by engineered Escherichia coli".BIORESOURCE TECHNOLOGY 114.114(2012):561-566.
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