Tailoring cyanobacterial cell factory for improved industrial properties

doi:10.1016/j.biotechadv.2018.01.005

QIBEBT-IR > 微生物代谢工程研究组

	Tailoring cyanobacterial cell factory for improved industrial properties
	Luan, Guodong1,2 ; Lu, Xuefeng 1,2,3
	2018-03-01
发表期刊	BIOTECHNOLOGY ADVANCES
ISSN	0734-9750
卷号	36 期号:2 页码:430-442
摘要	Photosynthetic biomanufacturing provides a promising solution for sustainable production of biofuels and biochemicals. Cyanobacteria are among the most promising microbial platforms for the construction of photosynthetic cell factories. Metabolic engineering of cyanobacteria has enabled effective photosynthetic synthesis of diverse natural or non-natural metabolites, while commercialization of photosynthetic biomanufacturing is usually restricted by process and economic feasibilities. In actual outdoor conditions, active cell growth and product synthesis is restricted to narrow light exposure windows of the day-night cycles and is threatened by diverse physical, chemical, and biological environmental stresses. For biomass harvesting and bioproduct recovery, energy and cost consuming processing and equipment is required, which further decreases the economic and environmental competitiveness of the entire process. To facilitate scaled photosynthetic biomanufacturing, lots of efforts have been made to engineer cyanobacterial cell properties required by robust & continual cultivation and convenient & efficient recovery. In this review, we specifically summarized recently reported engineering strategies on optimizing industrial properties of cyanobacterial cells. Through systematically re-editing the metabolism, morphology, mutualism interaction of cyanobacterial chassis cells, the adaptabilities and compatibilities of the cyanobacterial cell factories to the industrial process could be significantly improved. Cell growth and product synthesis of the tailored cyanobacterial cells could be expanded and maintained at night and in stressful environments, while convenient biomass harvesting could also be expected. For developing more feasible cyanobacterial photosynthetic biomanufacturing in large scale, we here propose the importance of tailoring industrial properties of cyanobacteria and outline the directions that should be exploited in the future.
文章类型	Review
关键词	Cyanobacteria Photosynthetic Biomanufacturing Metabolic Engineering Scaled Cultivation Day-night Cycles Cellular Robustness Biocontaminants Resistance Biomass Harvest Product Recovery
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
DOI	10.1016/j.biotechadv.2018.01.005
关键词[WOS]	SP PCC 6803 ; OBLIGATE PHOTOAUTOTROPHIC CYANOBACTERIUM ; APHANOTHECE-HALOPHYTICA CONTAINS ; FRESH-WATER CYANOBACTERIUM ; SYNECHOCOCCUS-ELONGATUS ; CARBON-DIOXIDE ; ESCHERICHIA-COLI ; PHOTOSYNTHETIC PRODUCTION ; STRESS TOLERANCE ; CHEMICAL PRODUCTION
收录类别	SCI
语种	英语
WOS研究方向	Biotechnology & Applied Microbiology
项目资助者	National Science Foundation(31525002 ; Shandong Natural Science Foundation(JQ201306 ; Shandong Province (Taishan Scholarship) ; City of Qingdao (Qingdao Innovative Leading Talent) ; 31600034 ; ZR2017ZB0211) ; 3171101192 ; 31770092)
WOS类目	Biotechnology & Applied Microbiology
WOS记录号	WOS:000428823300007
出版者	PERGAMON-ELSEVIER SCIENCE LTD
引用统计
文献类型	期刊论文
条目标识符	http://ir.qibebt.ac.cn/handle/337004/10752
专题	微生物代谢工程研究组
通讯作者	Lu, Xuefeng
作者单位	1.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Key Lab Biofuels, 189 Songling Rd, Qingdao 266101, Peoples R China 2.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Shandong Prov Key Lab Synthet Biol, 189 Songling Rd, Qingdao 266101, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
推荐引用方式 GB/T 7714	Luan, Guodong,Lu, Xuefeng. Tailoring cyanobacterial cell factory for improved industrial properties[J]. BIOTECHNOLOGY ADVANCES,2018,36(2):430-442.
APA	Luan, Guodong,&Lu, Xuefeng.(2018).Tailoring cyanobacterial cell factory for improved industrial properties.BIOTECHNOLOGY ADVANCES,36(2),430-442.
MLA	Luan, Guodong,et al."Tailoring cyanobacterial cell factory for improved industrial properties".BIOTECHNOLOGY ADVANCES 36.2(2018):430-442.