Chitosan-Based Thermo/pH Double Sensitive Hydrogel for Controlled Drug Delivery

doi:10.1002/mabi.201700305

QIBEBT-IR

	Chitosan-Based Thermo/pH Double Sensitive Hydrogel for Controlled Drug Delivery
	Bai, Xiaoyu 1; Bao, Zixian 2; Bi, Shichao 1; Li, Yang 1; Yu, Xiaoping 1; Hu, Shihao 1; Tian, Meiping 1; Zhang, Xin 1; Cheng, Xiaojie 1; Chen, Xiguang 1,3
	2018-03-01
发表期刊	MACROMOLECULAR BIOSCIENCE
ISSN	1616-5187
卷号	18 期号:3
摘要	A series of thermo/pH sensitive N-succinyl hydroxybutyl chitosan (NSHBC) hydrogels with different substitution degrees of succinyl are prepared for drug delivery. Rheology analysis shows that the gelation temperature of NSHBC hydrogels is 3.8 degrees C higher than that of hydroxybutyl chitosan (HBC) hydrogels. A model drug bovine serum albumin (BSA) is successfully loaded and released. NSHBC hydrogels show excellent pH sensitivity drug release behaviors. After incubation for 24 h, 93.7% of BSA is released from NSHBC hydrogels in phosphate buffer saline (PBS) (pH 7.4), which is significantly greater than that of 24.6% at pH 3.0. In contrast, the release rate of BSA from HBC is about 70.0% at pH 3.0 and 7.4. Thus, these novel hydrogels have the prominent merits of high adaptability to soluble drugs and pH sensitivity triggered release, indicating that NSHBC hydrogels have promising applications in oral drug delivery.
文章类型	Article
关键词	Hydrogel Hydroxybutyl Chitosan Oral Delivery Thermo Ph Double Sensitive
WOS标题词	Science & Technology ; Life Sciences & Biomedicine ; Technology ; Physical Sciences
DOI	10.1002/mabi.201700305
关键词[WOS]	N-SUCCINYL-CHITOSAN ; HYDROXYBUTYL CHITOSAN ; ORAL DELIVERY ; THERMOSENSITIVE HYDROGEL ; BIOMEDICAL APPLICATIONS ; CARBOXYMETHYL CHITOSAN ; CONTROLLED-RELEASE ; INSULIN DELIVERY ; CROSS-LINKING ; IN-VITRO
收录类别	SCI
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Materials Science ; Polymer Science
项目资助者	National Natural Science Foundation of China(81671828) ; China Postdoctoral Science Foundation(2016M592246) ; Taishan Scholar Program, China
WOS类目	Biochemistry & Molecular Biology ; Materials Science, Biomaterials ; Polymer Science
WOS记录号	WOS:000426736000002
出版者	WILEY-V C H VERLAG GMBH
引用统计
文献类型	期刊论文
条目标识符	http://ir.qibebt.ac.cn/handle/337004/10688
专题	中国科学院青岛生物能源与过程研究所
通讯作者	Cheng, Xiaojie; Chen, Xiguang
作者单位	1.Ocean Univ China, Coll Marine Life Sci, Qingdao 266003, Peoples R China 2.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao 266101, Shandong, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Qingdao 266000, Peoples R China
推荐引用方式 GB/T 7714	Bai, Xiaoyu,Bao, Zixian,Bi, Shichao,et al. Chitosan-Based Thermo/pH Double Sensitive Hydrogel for Controlled Drug Delivery[J]. MACROMOLECULAR BIOSCIENCE,2018,18(3).
APA	Bai, Xiaoyu.,Bao, Zixian.,Bi, Shichao.,Li, Yang.,Yu, Xiaoping.,...&Chen, Xiguang.(2018).Chitosan-Based Thermo/pH Double Sensitive Hydrogel for Controlled Drug Delivery.MACROMOLECULAR BIOSCIENCE,18(3).
MLA	Bai, Xiaoyu,et al."Chitosan-Based Thermo/pH Double Sensitive Hydrogel for Controlled Drug Delivery".MACROMOLECULAR BIOSCIENCE 18.3(2018).