| Cytotoxic Polyketides with an Oxygen-Bridged Cyclooctadiene Core Skeleton from the Mangrove Endophytic Fungus Phomosis sp. A818 | |
| Wei Zhang; Baobing Zhao; Liangcheng Du; Yuemao Shen | |
| 2017 | |
| 发表期刊 | Molecules
 |
| 卷号 | 22页码:1547-1555 |
| 摘要 | Plant endophytic microorganisms represent a largely untapped resource for new bioactive natural products. Eight polyketide natural products were isolated from a mangrove endophytic fungus Phomosis sp. A818. The structural elucidation of these compounds revealed that they share a distinct feature in their chemical structures, an oxygen-bridged cyclooctadiene core skeleton. The study on their structure–activity relationship showed that the α,β -unsaturated -lactone moiety, as exemplified in compounds 1 and 2, was critical to the cytotoxic activity of these compounds. In addition, compound 4 might be a potential agonist of AMPK (50-adenosine monophosphate-activated protein kinase). |
| 文章类型 | Article |
| DOI | doi:10.3390/molecules22091547 |
| 关键词[WOS] | polyketide ; mycoepoxydiene ; cyclooctadiene ; endophtic fungus ; cytotoxicity |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS研究方向 | Microbiology |
| 项目资助者 | NSFC (31570030) ; Youth Innovation Promotion Association CAS to W.Z. (2015166) ; Nebraska Research Initiatives ; China Postdoctoral Science Found (2015M580606 and 2016M580606). |
| WOS类目 | Microbiology |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qibebt.ac.cn/handle/337004/9858 |
| 专题 | 酶工程研究组 |
| 推荐引用方式 GB/T 7714 | Wei Zhang,Baobing Zhao,Liangcheng Du,et al. Cytotoxic Polyketides with an Oxygen-Bridged Cyclooctadiene Core Skeleton from the Mangrove Endophytic Fungus Phomosis sp. A818[J]. Molecules,2017,22:1547-1555. |
| APA | Wei Zhang,Baobing Zhao,Liangcheng Du,&Yuemao Shen.(2017).Cytotoxic Polyketides with an Oxygen-Bridged Cyclooctadiene Core Skeleton from the Mangrove Endophytic Fungus Phomosis sp. A818.Molecules,22,1547-1555. |
| MLA | Wei Zhang,et al."Cytotoxic Polyketides with an Oxygen-Bridged Cyclooctadiene Core Skeleton from the Mangrove Endophytic Fungus Phomosis sp. A818".Molecules 22(2017):1547-1555. |
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| Cytotoxic Polyketide（1197KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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