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Cytotoxic Polyketides with an Oxygen-Bridged Cyclooctadiene Core Skeleton from the Mangrove Endophytic Fungus Phomosis sp. A818
Wei Zhang; Baobing Zhao; Liangcheng Du; Yuemao Shen
2017
发表期刊Molecules
卷号22页码:1547-1555
摘要Plant endophytic microorganisms represent a largely untapped resource for new bioactive natural products. Eight polyketide natural products were isolated from a mangrove endophytic fungus Phomosis sp. A818. The structural elucidation of these compounds revealed that they share a distinct feature in their chemical structures, an oxygen-bridged cyclooctadiene core skeleton. The study on their structure–activity relationship showed that the α,β -unsaturated -lactone moiety, as exemplified in compounds 1 and 2, was critical to the cytotoxic activity of these compounds. In addition, compound 4 might be a potential agonist of AMPK (50-adenosine monophosphate-activated protein kinase).
文章类型Article
DOIdoi:10.3390/molecules22091547
关键词[WOS]polyketide ; mycoepoxydiene ; cyclooctadiene ; endophtic fungus ; cytotoxicity
收录类别SCI
语种英语
WOS研究方向Microbiology
项目资助者NSFC (31570030) ; Youth Innovation Promotion Association CAS to W.Z. (2015166) ; Nebraska Research Initiatives ; China Postdoctoral Science Found (2015M580606 and 2016M580606).
WOS类目Microbiology
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文献类型期刊论文
条目标识符http://ir.qibebt.ac.cn/handle/337004/9858
专题酶工程研究组
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Wei Zhang,Baobing Zhao,Liangcheng Du,et al. Cytotoxic Polyketides with an Oxygen-Bridged Cyclooctadiene Core Skeleton from the Mangrove Endophytic Fungus Phomosis sp. A818[J]. Molecules,2017,22:1547-1555.
APA Wei Zhang,Baobing Zhao,Liangcheng Du,&Yuemao Shen.(2017).Cytotoxic Polyketides with an Oxygen-Bridged Cyclooctadiene Core Skeleton from the Mangrove Endophytic Fungus Phomosis sp. A818.Molecules,22,1547-1555.
MLA Wei Zhang,et al."Cytotoxic Polyketides with an Oxygen-Bridged Cyclooctadiene Core Skeleton from the Mangrove Endophytic Fungus Phomosis sp. A818".Molecules 22(2017):1547-1555.
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