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A Post Processing Method for Optimizing Synthesis Strategy for Oligonucleotide Microarrays
Kang Ning; Kwok Pui Choi; Hon Wai Leong; Louxin Zhang
2005
发表期刊Nucleic Acids Research
期号11
摘要The broad applicability of gene expression profiling to genomic analyses has generated huge demand for

mass production of microarrays and hence for improving the cost effectiveness of microarray fabrication. We developed a post-processing method for deriving a good synthesis strategy. In this paper, we assessed all the known efficient methods and our post-processing method for reducing the number of synthesis cycles for manufacturing a DNA-chip of a given set of oligos. Our experimental results on both simulated and 52 real datasets show that no single method consistently gives the best synthesis strategy, and post-processing an existing strategy is necessary as it often reduces the number of synthesis cycles further.

; The broad applicability of gene expression profiling to genomic analyses has generated huge demand for

mass production of microarrays and hence for improving the cost effectiveness of microarray fabrication. We developed a post-processing method for deriving a good synthesis strategy. In this paper, we assessed all the known efficient methods and our post-processing method for reducing the number of synthesis cycles for manufacturing a DNA-chip of a given set of oligos. Our experimental results on both simulated and 52 real datasets show that no single method consistently gives the best synthesis strategy, and post-processing an existing strategy is necessary as it often reduces the number of synthesis cycles further.

关键词a Post Processing Method For Optimizing Synthesis Strategy For Oligonucleotide Microarrays
学科领域功能基因组
文献类型期刊论文
条目标识符http://ir.qibebt.ac.cn/handle/337004/980
专题单细胞中心组群
推荐引用方式
GB/T 7714
Kang Ning,Kwok Pui Choi,Hon Wai Leong,et al. A Post Processing Method for Optimizing Synthesis Strategy for Oligonucleotide Microarrays[J]. Nucleic Acids Research,2005(11).
APA Kang Ning,Kwok Pui Choi,Hon Wai Leong,&Louxin Zhang.(2005).A Post Processing Method for Optimizing Synthesis Strategy for Oligonucleotide Microarrays.Nucleic Acids Research(11).
MLA Kang Ning,et al."A Post Processing Method for Optimizing Synthesis Strategy for Oligonucleotide Microarrays".Nucleic Acids Research .11(2005).
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