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Enzymatic hydrogelation of self-assembling peptide I4K2 and its antibacterial and drug sustained-release activities
Bai, Jingkun1,2; Gong, Zhongying1; Wang, Jingxin2; Wang, Chengdong3
2017
发表期刊RSC ADVANCES
卷号7期号:77页码:48631-48638
摘要Hydrogels provide great potential for biomedical applications. For clinical use, hydrogels could be used as scaffold materials for cell culture, regenerative medicine and drugs release with bactericidal properties. The amphiphilic peptide I4K2 is designed to inhibit bacterial growth through membrane permeation mechanisms. I4K2 is found to be able to self-assemble into nanofibers and form hydrogels in the presence of an enzyme (plasma amine oxidase, PAO). HPLC and MALDI-TOF-MS data show that PAO promoted the oxidation of the 3-amine of the lysine side chain. The cross-linking of I4K2 molecules catalyzed by PAO leads to a decrease in the amount of the positive charge of the system, which enhances the interaction between the self-assembled nanofibers and contributes to the formation of hydrogels. This self-supported hydrogel showed antibacterial activity against both G(+) and G(-) bacteria and has low cytotoxicity, which enable it be consequently used as an antimicrobial agent or biological engineering scaffold material. The hydrogel also possesses good drug sustained-release activities. These advantages result in the great potential of this enzymatic I4K2 hydrogel for biomedical applications.
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
DOI10.1039/c7ra09743c
关键词[WOS]PLASMA AMINE OXIDASE ; 3D CELL-CULTURE ; SUPRAMOLECULAR HYDROGELS ; LYSYL OXIDASE ; MOLECULAR-MECHANISMS ; DELIVERY VEHICLES ; CROSS-LINKING ; PLANT-TISSUE ; DESTABILIZATION ; AMPHIPHILES
收录类别SCI
语种英语
WOS研究方向Chemistry
项目资助者Weifang Medical University
WOS类目Chemistry, Multidisciplinary
WOS记录号WOS:000413777800010
引用统计
文献类型期刊论文
条目标识符http://ir.qibebt.ac.cn/handle/337004/9736
专题仿生与固态能源系统研究组
作者单位1.Weifang Med Univ, Sch Biosci & Technol, Shandong Prov Key Lab Biopharmaceut, 7166 Baotong West St, Weifang 261042, Peoples R China
2.China Univ Petr East China, Ctr Bioengn & Biotechnol, 66 Changjiang West Rd, Qingdao 266580, Peoples R China
3.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao Ind Energy Storage Res Inst, Qingdao 266101, Peoples R China
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GB/T 7714
Bai, Jingkun,Gong, Zhongying,Wang, Jingxin,et al. Enzymatic hydrogelation of self-assembling peptide I4K2 and its antibacterial and drug sustained-release activities[J]. RSC ADVANCES,2017,7(77):48631-48638.
APA Bai, Jingkun,Gong, Zhongying,Wang, Jingxin,&Wang, Chengdong.(2017).Enzymatic hydrogelation of self-assembling peptide I4K2 and its antibacterial and drug sustained-release activities.RSC ADVANCES,7(77),48631-48638.
MLA Bai, Jingkun,et al."Enzymatic hydrogelation of self-assembling peptide I4K2 and its antibacterial and drug sustained-release activities".RSC ADVANCES 7.77(2017):48631-48638.
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