| Natural and engineered polyhydroxyalkanoate (PHA) synthase: key enzyme in biopolyester production | |
Zou, Huibin1,2; Shi, Mengxun1; Zhang, Tongtong1; Li, Lei1; Li, Liangzhi3; Xian, Mo2
| |
| 2017-10-01 | |
| 发表期刊 | APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
 |
| 卷号 | 101期号:20页码:7417-7426 |
| 摘要 | With the finite supply of petroleum and increasing concern with environmental issues associated with their harvest and processing, the development of more eco-friendly, sustainable alternative biopolymers that can effectively fill the role of petro-polymers has become a major focus. Polyhydroxyalkanoate (PHA) can be naturally produced by many species of bacteria and the PHA synthase is believed to be key enzyme in this natural pathway. Natural PHA synthases are diverse and can affect the properties of the produced PHAs, such as monomer composition, molecular weights, and material properties. Moreover, recent studies have led to major advances in the searching of PHA synthases that display specific properties, as well as engineering efforts that offer more efficient PHA synthases, increased PHA compound production, or even novel biopolyesters which cannot be naturally produced. In this article, we review the updated information of natural PHA synthases and their engineering strategies for improved performance in polyester production. We also speculate future trends on the development of robust PHA synthases and their application in biopolyester production. |
| 文章类型 | Review |
| 关键词 | Polyhydroxyalkanoate Phasynthase Enzyme Engineering Biopolyester |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| DOI | 10.1007/s00253-017-8485-0 |
| 关键词[WOS] | RECOMBINANT ESCHERICHIA-COLI ; IN-VITRO EVOLUTION ; PSEUDOMONAS SP 61-3 ; RALSTONIA-EUTROPHA ; SUBSTRATE-SPECIFICITY ; MOLECULAR CHARACTERIZATION ; CHEMOENZYMATIC SYNTHESIS ; SATURATION MUTAGENESIS ; BENEFICIAL MUTATION ; COA TRANSFERASE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS研究方向 | Biotechnology & Applied Microbiology |
| 项目资助者 | Shandong Province Natural Science Foundation(ZR2015BM011) ; Technology Development Project of Shandong Province(2016GSF121013) ; National Natural Science Foundation(21376156) |
| WOS类目 | Biotechnology & Applied Microbiology |
| WOS记录号 | WOS:000412122100001 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qibebt.ac.cn/handle/337004/9599 |
| 专题 | 生物基材料组群 |
| 作者单位 | 1.Qingdao Univ Sci & Technol, Coll Chem Engn, Qingdao 266042, Peoples R China 2.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, CAS Key Lab Biobased Mat, Qingdao, Peoples R China 3.Suzhou Univ Sci & Technol, Sch Chem Biol & Mat Engn, Suzhou 215009, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zou, Huibin,Shi, Mengxun,Zhang, Tongtong,et al. Natural and engineered polyhydroxyalkanoate (PHA) synthase: key enzyme in biopolyester production[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2017,101(20):7417-7426. |
| APA | Zou, Huibin,Shi, Mengxun,Zhang, Tongtong,Li, Lei,Li, Liangzhi,&Xian, Mo.(2017).Natural and engineered polyhydroxyalkanoate (PHA) synthase: key enzyme in biopolyester production.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,101(20),7417-7426. |
| MLA | Zou, Huibin,et al."Natural and engineered polyhydroxyalkanoate (PHA) synthase: key enzyme in biopolyester production".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 101.20(2017):7417-7426. |
| 条目包含的文件 | 条目无相关文件。 | |||||
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论