Expansion of chemical space for natural products by uncommon P450 reactions

doi:10.1039/c7np00028f

QIBEBT-IR > 酶工程研究组

	Expansion of chemical space for natural products by uncommon P450 reactions
	Zhang, Xingwang; Li, Shengying
	2017-09-01
发表期刊	NATURAL PRODUCT REPORTS
卷号	34 期号:9 页码:1061-1089
摘要	C Cytochrome P450 enzymes (P450s) are the most versatile biocatalysts in nature. The catalytic competence of these extraordinary hemoproteins is broadly harnessed by numerous chemical defenders such as bacteria, fungi, and plants for the generation of diverse and complex natural products. Rather than the common tailoring reactions (e.g. hydroxylation and epoxidation) mediated by the majority of biosynthetic P450s, in this review, we will focus on the unusual P450 enzymes in relation to new chemistry, skeleton construction, and structure re-shaping via their own unique catalytic power or the intriguing protein-protein interactions between P450s and other proteins. These uncommon P450 reactions lead to a higher level of chemical space expansion for natural products, through which a broader spectrum of bioactivities can be gained by the host organisms.
文章类型	Review
WOS标题词	Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
DOI	10.1039/c7np00028f
关键词[WOS]	FLAVIOLIN SUBSTRATE MOLECULES ; STREPTOMYCES-COELICOLOR A3(2) ; TROPANE ALKALOID BIOSYNTHESIS ; FATTY-ACID DECARBOXYLASE ; PHENOL COUPLING REACTION ; CYTOCHROME-P450 MONOOXYGENASE ; MULTIFUNCTIONAL CYTOCHROME-P450 ; VANCOMYCIN BIOSYNTHESIS ; COMBINATORIAL BIOSYNTHESIS ; POLYKETIDE SYNTHASE
收录类别	SCI
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry
项目资助者	National Natural Science Foundation of China(NSFC 31422002) ; Natural Science Foundation of Shandong Province(JQ201407) ; Chinese Academy of Sciences(QYZDB-SSW-SMC042)
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic
WOS记录号	WOS:000409009000003
引用统计	被引频次：141[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qibebt.ac.cn/handle/337004/9558
专题	酶工程研究组
作者单位	Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Shandong Prov Key Lab Synthet Biol, CAS Key Lab Biofuels, Qingdao 266101, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Xingwang,Li, Shengying. Expansion of chemical space for natural products by uncommon P450 reactions[J]. NATURAL PRODUCT REPORTS,2017,34(9):1061-1089.
APA	Zhang, Xingwang,&Li, Shengying.(2017).Expansion of chemical space for natural products by uncommon P450 reactions.NATURAL PRODUCT REPORTS,34(9),1061-1089.
MLA	Zhang, Xingwang,et al."Expansion of chemical space for natural products by uncommon P450 reactions".NATURAL PRODUCT REPORTS 34.9(2017):1061-1089.