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An in vitro synthetic biosystem based on acetate for production of phloroglucinol
Zhang, Rubing1,2; Liu, Wei1; Cao, Yujin1; Xu, Xin1,2; Xian, Mo1; Liu, Huizhou1
2017-08-08
发表期刊BMC BIOTECHNOLOGY
卷号17
摘要Background: Phloroglucinol is an important chemical, and the biosynthesis processes which can convert glucose to phloroglucinol have been established. However, due to approximate 80% of the glucose being transformed into undesirable by-products and biomass, this biosynthesis process only shows a low yield with the highest value of about 0.20 g/g. The industrial applications are usually hindered by the low current productivity and yield and also by the high costs. Generally, several different aspects limit the development of phloroglucinol biosynthesis. The yield of phloroglucinol is one of the most important parameters for its bioconversion especially from economic and ecological points of view. The in vitro biosynthesis of bio-based chemicals, is a flexible alternative with potentially high-yield to in vivo biosynthetic technology.
文章类型Article
关键词In Vitro Acetate Acetyl-coa Synthetase Phloroglucinol High Yield
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1186/s12896-017-0376-z
关键词[WOS]ENGINEERING ESCHERICHIA-COLI ; ACETYL-COA CARBOXYLASE ; ACID ; BIOSYNTHESIS ; COENZYME ; GLYCEROL ; FERMENTATION ; ACCUMULATION ; EXPRESSION ; CHEMICALS
收录类别SCI
语种英语
WOS研究方向Biotechnology & Applied Microbiology
项目资助者National Natural Science Foundation of China(21376255 ; Taishan Scholars Climbing Program of Shandong(tspd20150210) ; 21572242)
WOS类目Biotechnology & Applied Microbiology
WOS记录号WOS:000408016900001
引用统计
文献类型期刊论文
条目标识符http://ir.qibebt.ac.cn/handle/337004/9553
专题生物基材料组群
作者单位1.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, CAS Key Lab Biobased Mat, Qingdao 266101, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Zhang, Rubing,Liu, Wei,Cao, Yujin,et al. An in vitro synthetic biosystem based on acetate for production of phloroglucinol[J]. BMC BIOTECHNOLOGY,2017,17.
APA Zhang, Rubing,Liu, Wei,Cao, Yujin,Xu, Xin,Xian, Mo,&Liu, Huizhou.(2017).An in vitro synthetic biosystem based on acetate for production of phloroglucinol.BMC BIOTECHNOLOGY,17.
MLA Zhang, Rubing,et al."An in vitro synthetic biosystem based on acetate for production of phloroglucinol".BMC BIOTECHNOLOGY 17(2017).
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