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Malonyl-CoA pathway: a promising route for 3-hydroxypropionate biosynthesis
Liu, Changshui1,2; Ding, Yamei2; Xian, Mo1; Liu, Min1; Liu, Huizhou1; Ma, Qingjun2; Zhao, Guang1
2017
发表期刊CRITICAL REVIEWS IN BIOTECHNOLOGY
卷号37期号:7页码:933-941
摘要3-Hydroxypropionate (3HP) is an attractive platform chemical, serving as a precursor to a variety of commodity chemicals like acrylate and acrylamide, as well as a monomer of a biodegradable plastic. To establish a sustainable way to produce these commercially important chemicals and materials, fermentative production of 3HP is widely investigated in recent years. It is reported that 3HP can be produced from several intermediates, such as glycerol, malonyl-CoA, and beta-alanine. Among all these biosynthetic routes, the malonyl-CoA pathway has some distinct advantages, including a broad feedstock spectrum, thermodynamic feasibility, and redox neutrality. To date, this pathway has been successfully constructed in various species including Escherichia coli, yeast and cyanobacteria, and optimized through carbon flux redirection, enzyme screening and engineering, and an increasing supply of energy and cofactors, resulting in significantly enhanced 3HP titer up to 40 g/L. These results show the feasibility of commercial manufacturing of 3HP and its derivatives in the future.
文章类型Review
关键词3-hydroxypropionate Malonyl-coa Pathway Metabolic Engineering Acetyl-coa Carboxylase Malonyl-coa Reductase Carbon Flux Enzyme Engineering Supply Of Energy And cOfactor 3hp Tolerance
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1080/07388551.2016.1272093
关键词[WOS]RECOMBINANT ESCHERICHIA-COLI ; AUTOTROPHIC CARBON FIXATION ; COENZYME-A REDUCTASE ; ACETYL-COA ; CHLOROFLEXUS-AURANTIACUS ; SACCHAROMYCES-CEREVISIAE ; PYROCOCCUS-FURIOSUS ; ACID PRODUCTION ; FATTY-ACIDS ; ACETATE
收录类别SCI
语种英语
WOS研究方向Biotechnology & Applied Microbiology
项目资助者100-Talent Project of CAS ; CAS Key Program(ZDRW-ZS-2016-3M) ; Taishan Scholars Climbing Program of Shandong(TSPD20150210) ; National Natural Science Foundation of China(31670089)
WOS类目Biotechnology & Applied Microbiology
WOS记录号WOS:000407365200009
引用统计
文献类型期刊论文
条目标识符http://ir.qibebt.ac.cn/handle/337004/9546
专题生物基材料组群
作者单位1.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, CAS Key Lab Biobased Mat, Qingdao, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Qingdao, Peoples R China
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Liu, Changshui,Ding, Yamei,Xian, Mo,et al. Malonyl-CoA pathway: a promising route for 3-hydroxypropionate biosynthesis[J]. CRITICAL REVIEWS IN BIOTECHNOLOGY,2017,37(7):933-941.
APA Liu, Changshui.,Ding, Yamei.,Xian, Mo.,Liu, Min.,Liu, Huizhou.,...&Zhao, Guang.(2017).Malonyl-CoA pathway: a promising route for 3-hydroxypropionate biosynthesis.CRITICAL REVIEWS IN BIOTECHNOLOGY,37(7),933-941.
MLA Liu, Changshui,et al."Malonyl-CoA pathway: a promising route for 3-hydroxypropionate biosynthesis".CRITICAL REVIEWS IN BIOTECHNOLOGY 37.7(2017):933-941.
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