Malonyl-CoA pathway: a promising route for 3-hydroxypropionate biosynthesis | |
Liu, Changshui1,2; Ding, Yamei2; Xian, Mo1; Liu, Min1; Liu, Huizhou1; Ma, Qingjun2; Zhao, Guang1 | |
2017 | |
发表期刊 | CRITICAL REVIEWS IN BIOTECHNOLOGY |
卷号 | 37期号:7页码:933-941 |
摘要 | 3-Hydroxypropionate (3HP) is an attractive platform chemical, serving as a precursor to a variety of commodity chemicals like acrylate and acrylamide, as well as a monomer of a biodegradable plastic. To establish a sustainable way to produce these commercially important chemicals and materials, fermentative production of 3HP is widely investigated in recent years. It is reported that 3HP can be produced from several intermediates, such as glycerol, malonyl-CoA, and beta-alanine. Among all these biosynthetic routes, the malonyl-CoA pathway has some distinct advantages, including a broad feedstock spectrum, thermodynamic feasibility, and redox neutrality. To date, this pathway has been successfully constructed in various species including Escherichia coli, yeast and cyanobacteria, and optimized through carbon flux redirection, enzyme screening and engineering, and an increasing supply of energy and cofactors, resulting in significantly enhanced 3HP titer up to 40 g/L. These results show the feasibility of commercial manufacturing of 3HP and its derivatives in the future. |
文章类型 | Review |
关键词 | 3-hydroxypropionate Malonyl-coa Pathway Metabolic Engineering Acetyl-coa Carboxylase Malonyl-coa Reductase Carbon Flux Enzyme Engineering Supply Of Energy And cOfactor 3hp Tolerance |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
DOI | 10.1080/07388551.2016.1272093 |
关键词[WOS] | RECOMBINANT ESCHERICHIA-COLI ; AUTOTROPHIC CARBON FIXATION ; COENZYME-A REDUCTASE ; ACETYL-COA ; CHLOROFLEXUS-AURANTIACUS ; SACCHAROMYCES-CEREVISIAE ; PYROCOCCUS-FURIOSUS ; ACID PRODUCTION ; FATTY-ACIDS ; ACETATE |
收录类别 | SCI |
语种 | 英语 |
WOS研究方向 | Biotechnology & Applied Microbiology |
项目资助者 | 100-Talent Project of CAS ; CAS Key Program(ZDRW-ZS-2016-3M) ; Taishan Scholars Climbing Program of Shandong(TSPD20150210) ; National Natural Science Foundation of China(31670089) |
WOS类目 | Biotechnology & Applied Microbiology |
WOS记录号 | WOS:000407365200009 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.qibebt.ac.cn/handle/337004/9546 |
专题 | 生物基材料组群 |
作者单位 | 1.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, CAS Key Lab Biobased Mat, Qingdao, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Qingdao, Peoples R China |
推荐引用方式 GB/T 7714 | Liu, Changshui,Ding, Yamei,Xian, Mo,et al. Malonyl-CoA pathway: a promising route for 3-hydroxypropionate biosynthesis[J]. CRITICAL REVIEWS IN BIOTECHNOLOGY,2017,37(7):933-941. |
APA | Liu, Changshui.,Ding, Yamei.,Xian, Mo.,Liu, Min.,Liu, Huizhou.,...&Zhao, Guang.(2017).Malonyl-CoA pathway: a promising route for 3-hydroxypropionate biosynthesis.CRITICAL REVIEWS IN BIOTECHNOLOGY,37(7),933-941. |
MLA | Liu, Changshui,et al."Malonyl-CoA pathway: a promising route for 3-hydroxypropionate biosynthesis".CRITICAL REVIEWS IN BIOTECHNOLOGY 37.7(2017):933-941. |
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