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Title:
Identification of residues important for the activity of aldehyde-deformylating oxygenase through investigation into the structure-activity relationship
Author: Wang, Qing1,2; Bao, Luyao1,2; Jia, Chenjun2,3; Li, Mei3; Li, Jian-Jun1,4; Lu, Xuefeng1
Source: BMC BIOTECHNOLOGY
Issued Date: 2017-03-16
Volume: 17
Keyword: Aldehyde-deformylating oxygenase ; Site-directed mutagenesis ; Structure-activity relationship ; Fatty alk(a/e) ne ; Synechococcus elongatus PCC7942 ; Synechocystis sp PCC6803
DOI: 10.1186/s12896-017-0351-8
DOC Type: Article
English Abstract: Background: Aldehyde-deformylating oxygenase (ADO) is a key enzyme involved in the biosynthetic pathway of fatty alk(a/e)nes in cyanobacteria. However, cADO (cyanobacterial ADO) showed extreme low activity with the k(cat) value below 1 min(-1), which would limit its application in biofuel production. To identify the activity related key residues of cADO is urgently required.
WOS Headings: Science & Technology ; Life Sciences & Biomedicine
WOS Subject: Biotechnology & Applied Microbiology
WOS Subject Extended: Biotechnology & Applied Microbiology
WOS Keyword Plus: CYANOBACTERIAL ALDEHYDE ; FATTY ALDEHYDES ; DECARBONYLASE ; CONVERSION ; ALKANES ; INSIGHTS ; ENZYMES ; FORMATE
Indexed Type: SCI
Funder: National Basic Research Program of China (973)(2011CBA00907 ; National Science Foundation of China(31170765 ; CAS Cross and Cooperation Team for Scientific Innovation(Y31102110A) ; Shandong Natural Science Foundation(JQ201306) ; Shandong Taishan Scholarship ; 2011CBA00902) ; 31370799)
Language: 英语
WOS ID: WOS:000396668000001
Citation statistics:
Content Type: 期刊论文
URI: http://ir.qibebt.ac.cn/handle/337004/9351
Appears in Collections:微生物代谢工程团队_期刊论文

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description.institution: 1.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Key Lab Biofuels, Shandong Prov Key Lab Energy Genet, Qingdao 266101, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China
4.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China

Recommended Citation:
Wang, Qing,Bao, Luyao,Jia, Chenjun,et al. Identification of residues important for the activity of aldehyde-deformylating oxygenase through investigation into the structure-activity relationship[J]. BMC BIOTECHNOLOGY,2017,17.
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