| Eluent Tolerance and Enantioseparation Recovery of Chiral Packing Materials Based on Chitosan Bis(Phenylcarbamate)-(n-Octyl Urea)s for High Performance Liquid Chromatography | |
| Wang, Jing1; Huang, Shao-Hua2; Chen, Wei1; Bai, Zheng-Wu1 | |
| 2016-11-01 | |
| 发表期刊 | MOLECULES
 |
| 卷号 | 21期号:11 |
| 摘要 | The goal of the present work was to study the influence of the swelling of chitosan derivatives on the enantioseparation and the separation performance recovery of chiral stationary phases (CSPs) based on these derivatives. Therefore, six chitosan bis(phenylcarbamate)-(n-octyl urea)s were synthesized, which were coated on macroporous 3-aminopropyl silica gel affording new CSPs. Most of the CSPs demonstrated strong enantioseparation capability for the tested chiral compounds. The swelling capacity of the chitosan bis(phenylcarbamate)-(n-octyl urea) s in ethyl acetate, acetone and tetrahydrofuran (THF) was evaluated. Among the chitosan derivatives, the chitosan bis(3,5-dichlorophenylcarbamate)-(n-octyl urea) polymer showed the highest swelling capacity in ethyl acetate and THF. The polymer-based CSPs could be utilized with pure ethyl acetate and a normal phase containing 70% THF, but was damaged by pure THF. On the other hand, the separation performance of the damaged CSP could be recovered after it was allowed to stand for a period of time. The observations are important for the development and application of polysaccharide derivative-based CSPs. |
| 文章类型 | Article |
| 关键词 | Chitosan Chiral Packing Material Durability Chiral Recognition High Performance Liquid Chromatography |
| WOS标题词 | Science & Technology ; Physical Sciences |
| DOI | 10.3390/molecules21111528 |
| 关键词[WOS] | SUPERCRITICAL-FLUID CHROMATOGRAPHY ; STATIONARY PHASES ; POLYSACCHARIDE DERIVATIVES ; SEPARATION ; ENANTIOMERS ; AMYLOSE ; RECOGNITION ; CELLULOSE ; RESOLUTION ; SELECTORS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS研究方向 | Chemistry |
| 项目资助者 | National Natural Science Foundation of China(51373127) |
| WOS类目 | Chemistry, Organic |
| WOS记录号 | WOS:000389918200110 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qibebt.ac.cn/handle/337004/9208 |
| 专题 | 公共实验室 |
| 作者单位 | 1.Wuhan Inst Technol, Sch Chem & Environm Engn, Wuhan 430073, Peoples R China 2.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Key Lab Biobased Mat, Qingdao 266101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Jing,Huang, Shao-Hua,Chen, Wei,et al. Eluent Tolerance and Enantioseparation Recovery of Chiral Packing Materials Based on Chitosan Bis(Phenylcarbamate)-(n-Octyl Urea)s for High Performance Liquid Chromatography[J]. MOLECULES,2016,21(11). |
| APA | Wang, Jing,Huang, Shao-Hua,Chen, Wei,&Bai, Zheng-Wu.(2016).Eluent Tolerance and Enantioseparation Recovery of Chiral Packing Materials Based on Chitosan Bis(Phenylcarbamate)-(n-Octyl Urea)s for High Performance Liquid Chromatography.MOLECULES,21(11). |
| MLA | Wang, Jing,et al."Eluent Tolerance and Enantioseparation Recovery of Chiral Packing Materials Based on Chitosan Bis(Phenylcarbamate)-(n-Octyl Urea)s for High Performance Liquid Chromatography".MOLECULES 21.11(2016). |
| 条目包含的文件 | 条目无相关文件。 | |||||
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