Resonance assignments of a VapC family toxin from Clostridium thermocellum

doi:10.1007/s12104-016-9702-y

QIBEBT-IR > 代谢物组学研究组

	Resonance assignments of a VapC family toxin from Clostridium thermocellum
	Wang, Chen 1,2,3; Xuan, Jinsong 1; Cui, Qiu2,3 ; Feng, Yingang2,3
	2016-10-01
发表期刊	BIOMOLECULAR NMR ASSIGNMENTS
卷号	10 期号:2 页码:367-371
摘要	Toxin-antitoxin (TA) systems widely exist in bacterial plasmids, phages, and chromosomes and play important roles in growth persistence and host-pathogen interaction. Virulence associated protein BC (VapBC) family TAs are the most abundant TAs in bacteria and many pathogens contain a large number of vapBC loci in the genome which have been extensively studied. Clostridium thermocellum, a cellulolytic anaerobic gram-positive bacterium with promising applications in biofuel production, also contains a VapBC TA in the genome. Despite the structures of several VapBC family TAs have been determined, the toxin and anti-toxin components of C. thermocellum VapBC have very low sequence identity to the proteins in PDB. Therefore, the structure and functional mechanism of this TA is largely unknown. Here we reported the NMR resonance assignments of the VapC toxin from C. thermocellum as a basis for further structural and functional studies.
文章类型	Article
关键词	Vapbc Toxin-antitoxin Clostridium Thermocellum Nmr Chemical Shift Assignment
WOS标题词	Science & Technology ; Life Sciences & Biomedicine ; Technology
DOI	10.1007/s12104-016-9702-y
关键词[WOS]	ANTITOXIN SYSTEMS ; CRYSTAL-STRUCTURE ; MYCOBACTERIUM-TUBERCULOSIS ; REVEALS ; COMPLEX ; PERSISTENCE ; BACTERIA ; LOCI ; ION
收录类别	SCI
语种	英语
WOS研究方向	Biophysics ; Spectroscopy
项目资助者	National Natural Science Foundation of China(31270784 ; Chinese Government(201506465020) ; 31300635)
WOS类目	Biophysics ; Spectroscopy
WOS记录号	WOS:000388287400026
引用统计
文献类型	期刊论文
条目标识符	http://ir.qibebt.ac.cn/handle/337004/9103
专题	代谢物组学研究组
作者单位	1.Univ Sci & Technol Beijing, Sch Chem & Biol Engn, Dept Biol Sci & Engn, 30 Xueyuan Rd, Beijing 100083, Peoples R China 2.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Shandong Prov Key Lab Energy Genet, 189 Songling Rd, Qingdao 266101, Peoples R China 3.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, CAS Key Lab Biofuels, 189 Songling Rd, Qingdao 266101, Peoples R China
推荐引用方式 GB/T 7714	Wang, Chen,Xuan, Jinsong,Cui, Qiu,et al. Resonance assignments of a VapC family toxin from Clostridium thermocellum[J]. BIOMOLECULAR NMR ASSIGNMENTS,2016,10(2):367-371.
APA	Wang, Chen,Xuan, Jinsong,Cui, Qiu,&Feng, Yingang.(2016).Resonance assignments of a VapC family toxin from Clostridium thermocellum.BIOMOLECULAR NMR ASSIGNMENTS,10(2),367-371.
MLA	Wang, Chen,et al."Resonance assignments of a VapC family toxin from Clostridium thermocellum".BIOMOLECULAR NMR ASSIGNMENTS 10.2(2016):367-371.