| The Progress of Researches on Bacterial Type I Toxin-Antitoxin Systems | |
Wang Chen1,2,3,4; Xuan Jin-Song1; Feng Yin-Gang2,3,4
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| 2016-10-01 | |
| 发表期刊 | PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
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| 卷号 | 43期号:10页码:952-961 |
| 摘要 | Toxin-antitoxin (TA) loci encode two-component genetic elements: a stable "toxin" protein and an unstable "antitoxin" (a protein or a regulatory RNA) that neutralizes the toxin action. A lot of researches have been done on the cellular targets of toxins, the molecular structures and biological functions, and the mechanisms of antitoxin actions. The studies not only discovered a multitude of physiology roles of TA systems, but also led to a number of applications for various purposes. Currently, five TA systems have been discovered in countless bacteria and archaea. The antitoxins in type I systems are regulatory RNAs which can employ several different modes to counteract toxin proteins and their special RNA regulatory strategies have made type I TA systems become a focus of TA researches. Within this review, we will summarize our current knowledge on type I TA system and look into the future of their potential applications. |
| 文章类型 | Review |
| 关键词 | Type i Toxin-antitoxin System Regulatory Rna |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| DOI | 10.16476/j.pibb.2016.0217 |
| 关键词[WOS] | FAECALIS PLASMID PAD1 ; PAR ADDICTION MODULE ; LONG DIRECT REPEAT ; SOS-INDUCED TOXIN ; ESCHERICHIA-COLI ; ANTISENSE RNA ; BACILLUS-SUBTILIS ; CRYSTAL-STRUCTURE ; STAPHYLOCOCCUS-AUREUS ; MEMBRANE-PERMEABILITY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| 项目资助者 | National Natural Science Foundation of China(31270784 ; Chinese Government Scholarship(201506465020) ; 31300635) |
| WOS类目 | Biochemistry & Molecular Biology ; Biophysics |
| WOS记录号 | WOS:000386106800004 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qibebt.ac.cn/handle/337004/9072 |
| 专题 | 代谢物组学研究组 |
| 作者单位 | 1.Univ Sci & Technol Beijing, Sch Chem & Biol Engn, Dept Biol Sci & Engn, Beijing 100083, Peoples R China 2.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, CAS Key Lab Biofuels, Qingdao 266101, Peoples R China 3.Chinese Acad Sci, Qingdao Engn Lab Single Cell Oil, QingdaoInst Bioenergy & Bioproc Technol, Qingdao 266101, Peoples R China 4.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Shandong Key Lab Synthet Biol, Qingdao 266101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang Chen,Xuan Jin-Song,Feng Yin-Gang. The Progress of Researches on Bacterial Type I Toxin-Antitoxin Systems[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2016,43(10):952-961. |
| APA | Wang Chen,Xuan Jin-Song,&Feng Yin-Gang.(2016).The Progress of Researches on Bacterial Type I Toxin-Antitoxin Systems.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,43(10),952-961. |
| MLA | Wang Chen,et al."The Progress of Researches on Bacterial Type I Toxin-Antitoxin Systems".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 43.10(2016):952-961. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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