| Cetylpyridinium chloride mouth rinses alleviate experimental gingivitis by inhibiting dental plaque maturation | |
Teng, Fei1,2,3; He, Tao4 ; Huang, Shi2,3,5; Bo, Cun-Pei2,3; Li, Zhen6; Chang, Jin-Lan7; Liu, Ji-Quan8; Charbonneau, Duane4; Xu, Jian2,3; Li, Rui8; Ling, Jun-Qi1
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| 2016-09-01 | |
| Source Publication | INTERNATIONAL JOURNAL OF ORAL SCIENCE
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| Volume | 8Issue:3Pages:182-190 |
| Abstract | Oral rinses containing chemotherapeutic agents, such as cetylpyridinium chloride (CPC), can alleviate plaque-induced gingival infections, but how oral microbiota respond to these treatments in human population remains poorly understood. Via a double blinded, randomised controlled trial of 91 subjects, the impact of CPC-containing oral rinses on supragingival plaque was investigated in experimental gingivitis, where the subjects, after a 21-day period of dental prophylaxis to achieve healthy gingivae, received either CPC rinses or water for 21 days. Within-subject temporal dynamics of plaque microbiota and symptoms of gingivitis were profiled via 16S ribosomal DNA gene pyrosequencing and assessment with the Mazza gingival index. Cetylpyridinium chloride conferred gingival benefits, as progression of gingival inflammation resulting from a lack of dental hygiene was significantly slower in the mouth rinse group than in the water group due to inhibition of 17 gingivitis-enriched bacterial genera. Tracking of plaque alpha and beta diversity revealed that CPC treatment prevents acquisition of new taxa that would otherwise accumulate but maintains the original biodiversity of healthy plaques. Furthermore, CPC rinses reduced the size, local connectivity and microbiota-wide connectivity of the bacterial correlation network, particularly for nodes representing gingivitis enriched taxa. The findings of this study provide mechanistic insights into the impact of oral rinses on the progression and maturation of dental plaque in the natural human population. |
| Subtype | Article |
| Keyword | Cetylpyridinium Chloride Oral Microbiota Oral Rinse |
| WOS Headings | Science & Technology ; Life Sciences & Biomedicine |
| DOI | 10.1038/ijos.2016.18 |
| WOS Keyword | IN-VITRO ; ANTIMICROBIAL MOUTHRINSES ; ORAL MICROBIOTA ; EFFICACY ; HEALTH ; ANTIBACTERIAL ; PERIODONTITIS ; BIOFILMS ; DISEASES ; COMMUNITIES |
| Indexed By | SCI |
| Language | 英语 |
| WOS Research Area | Dentistry, Oral Surgery & Medicine |
| Funding Organization | Chinese Academy of Sciences ; Procter Gamble |
| WOS Subject | Dentistry, Oral Surgery & Medicine |
| WOS ID | WOS:000385468800007 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.qibebt.ac.cn/handle/337004/9060 |
| Collection | 单细胞中心组群 |
| Affiliation | 1.Sun Yat Sen Univ, Guanghua Sch & Hosp Stomatol, Dept Operat Dent & Endodont, Guangzhou 510055, Guangdong, Peoples R China 2.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Single Cell Ctr, Qingdao, Peoples R China 3.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Shandong Key Lab Energy Genet, Qingdao, Peoples R China 4.Procter & Gamble Mason Business Ctr, Dept Oral Care Clin Operat, Cincinnati, OH USA 5.Univ Chinese Acad Sci, Sino Danish Ctr Educ & Res, Beijing, Peoples R China 6.Beijing Union Med Coll Hosp, Dept Stomatol, Beijing, Peoples R China 7.Procter & Gamble Innovat Ctr, Global Microbiol Capabil Org, Beijing, Peoples R China 8.Procter & Gamble Int Operat SA, Global Microbiol Capabil Org, Singapore Branch, Singapore 138547, Singapore |
| Recommended Citation GB/T 7714 | Teng, Fei,He, Tao,Huang, Shi,et al. Cetylpyridinium chloride mouth rinses alleviate experimental gingivitis by inhibiting dental plaque maturation[J]. INTERNATIONAL JOURNAL OF ORAL SCIENCE,2016,8(3):182-190. |
| APA | Teng, Fei.,He, Tao.,Huang, Shi.,Bo, Cun-Pei.,Li, Zhen.,...&Ling, Jun-Qi.(2016).Cetylpyridinium chloride mouth rinses alleviate experimental gingivitis by inhibiting dental plaque maturation.INTERNATIONAL JOURNAL OF ORAL SCIENCE,8(3),182-190. |
| MLA | Teng, Fei,et al."Cetylpyridinium chloride mouth rinses alleviate experimental gingivitis by inhibiting dental plaque maturation".INTERNATIONAL JOURNAL OF ORAL SCIENCE 8.3(2016):182-190. |
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