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Cetylpyridinium chloride mouth rinses alleviate experimental gingivitis by inhibiting dental plaque maturation
Teng, Fei1,2,3; He, Tao4; Huang, Shi2,3,5; Bo, Cun-Pei2,3; Li, Zhen6; Chang, Jin-Lan7; Liu, Ji-Quan8; Charbonneau, Duane4; Xu, Jian2,3; Li, Rui8; Ling, Jun-Qi1
2016-09-01
Source PublicationINTERNATIONAL JOURNAL OF ORAL SCIENCE
Volume8Issue:3Pages:182-190
AbstractOral rinses containing chemotherapeutic agents, such as cetylpyridinium chloride (CPC), can alleviate plaque-induced gingival infections, but how oral microbiota respond to these treatments in human population remains poorly understood. Via a double blinded, randomised controlled trial of 91 subjects, the impact of CPC-containing oral rinses on supragingival plaque was investigated in experimental gingivitis, where the subjects, after a 21-day period of dental prophylaxis to achieve healthy gingivae, received either CPC rinses or water for 21 days. Within-subject temporal dynamics of plaque microbiota and symptoms of gingivitis were profiled via 16S ribosomal DNA gene pyrosequencing and assessment with the Mazza gingival index. Cetylpyridinium chloride conferred gingival benefits, as progression of gingival inflammation resulting from a lack of dental hygiene was significantly slower in the mouth rinse group than in the water group due to inhibition of 17 gingivitis-enriched bacterial genera. Tracking of plaque alpha and beta diversity revealed that CPC treatment prevents acquisition of new taxa that would otherwise accumulate but maintains the original biodiversity of healthy plaques. Furthermore, CPC rinses reduced the size, local connectivity and microbiota-wide connectivity of the bacterial correlation network, particularly for nodes representing gingivitis enriched taxa. The findings of this study provide mechanistic insights into the impact of oral rinses on the progression and maturation of dental plaque in the natural human population.
SubtypeArticle
KeywordCetylpyridinium Chloride Oral Microbiota Oral Rinse
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1038/ijos.2016.18
WOS KeywordIN-VITRO ; ANTIMICROBIAL MOUTHRINSES ; ORAL MICROBIOTA ; EFFICACY ; HEALTH ; ANTIBACTERIAL ; PERIODONTITIS ; BIOFILMS ; DISEASES ; COMMUNITIES
Indexed BySCI
Language英语
WOS Research AreaDentistry, Oral Surgery & Medicine
Funding OrganizationChinese Academy of Sciences ; Procter Gamble
WOS SubjectDentistry, Oral Surgery & Medicine
WOS IDWOS:000385468800007
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qibebt.ac.cn/handle/337004/9060
Collection单细胞中心
Affiliation1.Sun Yat Sen Univ, Guanghua Sch & Hosp Stomatol, Dept Operat Dent & Endodont, Guangzhou 510055, Guangdong, Peoples R China
2.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Single Cell Ctr, Qingdao, Peoples R China
3.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Shandong Key Lab Energy Genet, Qingdao, Peoples R China
4.Procter & Gamble Mason Business Ctr, Dept Oral Care Clin Operat, Cincinnati, OH USA
5.Univ Chinese Acad Sci, Sino Danish Ctr Educ & Res, Beijing, Peoples R China
6.Beijing Union Med Coll Hosp, Dept Stomatol, Beijing, Peoples R China
7.Procter & Gamble Innovat Ctr, Global Microbiol Capabil Org, Beijing, Peoples R China
8.Procter & Gamble Int Operat SA, Global Microbiol Capabil Org, Singapore Branch, Singapore 138547, Singapore
Recommended Citation
GB/T 7714
Teng, Fei,He, Tao,Huang, Shi,et al. Cetylpyridinium chloride mouth rinses alleviate experimental gingivitis by inhibiting dental plaque maturation[J]. INTERNATIONAL JOURNAL OF ORAL SCIENCE,2016,8(3):182-190.
APA Teng, Fei.,He, Tao.,Huang, Shi.,Bo, Cun-Pei.,Li, Zhen.,...&Ling, Jun-Qi.(2016).Cetylpyridinium chloride mouth rinses alleviate experimental gingivitis by inhibiting dental plaque maturation.INTERNATIONAL JOURNAL OF ORAL SCIENCE,8(3),182-190.
MLA Teng, Fei,et al."Cetylpyridinium chloride mouth rinses alleviate experimental gingivitis by inhibiting dental plaque maturation".INTERNATIONAL JOURNAL OF ORAL SCIENCE 8.3(2016):182-190.
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