Synthesis of novel chiral imidazolium stationary phases and their enantioseparation evaluation by high-performance liquid chromatography

doi:10.1016/j.aca.2016.09.018

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	Synthesis of novel chiral imidazolium stationary phases and their enantioseparation evaluation by high-performance liquid chromatography
	Wang, Tao 1; Yang, Haiyan2 ; Qiu, Ruchen 1; Huang, Shaohua 2
	2016-11-09
发表期刊	ANALYTICA CHIMICA ACTA
卷号	944 页码:70-77
摘要	Two novel chiral stationary phases (CSPs) were prepared by bonding chiral imidazoliums on the surface of silica gel. The chiral imidazoles were derivatized from chiral amines, 1-phenylethylamine and 1-(1naphthyl) ethylamine. The obtained CSPs were characterized by Fourier Transform Infrared (FT-IR) spectroscopy and elemental analysis (EA), demonstrating the bonding densities of CSP 1 and CSP 2 were 0.43 mmol g(-1) and 0.40 mmol g(-1), respectively. These two CSPs could be used to availably separate 8 pharmaceuticals, 7 mandelic acid/its derivatives, 2 1-phenylethylamine derivatives, 1 1,10-bi-2-naphthol, and 1 camphorsulfonic acid in high-performance liquid chromatography (HPLC). It is found that CSP 1 could effectively enantioseparate most chiral analytes, especially the acidic components, while CSP 2 could enantiorecognize all chiral analytes, although a number of components did not achieve baseline separation. Additionally, the effects of mobile phase composition, mobile phase pH and salt content, chiral selector structures, and analyte structures on the enantiorecognitions of the two CSPs were investigated. It is found that high acetonitrile content in mobile phases was conducive to enantior-ecognition. Mobile phase pH and salt content could alter the retention behaviors of different enantiomers of the same chiral compound, resulting in better enantioresolution. Moreover, both chiral selector structures and substituted groups of analytes played a significant role in the separation of chiral solutes. (C) 2016 Elsevier B.V. All rights reserved.
文章类型	Article
关键词	Chiral Imidazolium Ionic Liquid Chiral Stationary Phase High-performance Liquid Chromatography Enantioseparation
WOS标题词	Science & Technology ; Physical Sciences
DOI	10.1016/j.aca.2016.09.018
关键词[WOS]	NATURAL AMINO-ACIDS ; IONIC LIQUIDS ; CAPILLARY-ELECTROPHORESIS ; CYCLODEXTRINS ; RECOGNITION ; LIGANDS ; SEPARATION ; CHEMISTRY ; MEDIA
收录类别	SCI
语种	英语
WOS研究方向	Chemistry
项目资助者	National Natural Science Foundation of China(21105108) ; CAS Key Technology Talent Program
WOS类目	Chemistry, Analytical
WOS记录号	WOS:000385841200008
引用统计
文献类型	期刊论文
条目标识符	http://ir.qibebt.ac.cn/handle/337004/9059
专题	公共实验室
作者单位	1.Qingdao Univ Sci & Technol, Coll Chem Engn, Qingdao 266042, Peoples R China 2.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Shandong Prov Key Lab Synthet Biol, Qingdao 266101, Peoples R China
推荐引用方式 GB/T 7714	Wang, Tao,Yang, Haiyan,Qiu, Ruchen,et al. Synthesis of novel chiral imidazolium stationary phases and their enantioseparation evaluation by high-performance liquid chromatography[J]. ANALYTICA CHIMICA ACTA,2016,944:70-77.
APA	Wang, Tao,Yang, Haiyan,Qiu, Ruchen,&Huang, Shaohua.(2016).Synthesis of novel chiral imidazolium stationary phases and their enantioseparation evaluation by high-performance liquid chromatography.ANALYTICA CHIMICA ACTA,944,70-77.
MLA	Wang, Tao,et al."Synthesis of novel chiral imidazolium stationary phases and their enantioseparation evaluation by high-performance liquid chromatography".ANALYTICA CHIMICA ACTA 944(2016):70-77.