Improved Mechanical Properties and Sustained Release Behavior of Cationic Cellulose Nanocrystals Reinforeced Cationic Cellulose Injectable Hydrogels

doi:10.1021/acs.biomac.6b00646

QIBEBT-IR > 仿生智能材料研究组

	Improved Mechanical Properties and Sustained Release Behavior of Cationic Cellulose Nanocrystals Reinforeced Cationic Cellulose Injectable Hydrogels
	You, Jun1,2,3 ; Cao, Jinfeng 1,2; Zhao, Yanteng 4; Zhang, Lina 1,2; Zhou, Jinping 1,2; Chen, Yun 4
	2016-09-01
发表期刊	BIOMACROMOLECULES
卷号	17 期号:9 页码:2839-2848
摘要	Polysaccharide-based injectable hydrogels have several advantages in the context of biomedical use. However, the main obstruction associated with the utilization of these hydrogels in clinical application is their poor mechanical properties. Herein, we describe in situ gelling of nanocomposite hydrogels based on quaternized cellulose (QC) and rigid rod-like cationic cellulose nanocrystals (CCNCs), which can overcome,this challenge. In all cases, gelation immediately occurred with an increase of temperature, and the CCNCs were evenly distributed, throughout the hydrogels. The nanocomposite hydrogels exhibited increasing orders-of-magnitude in-the mechanical strength, high extension in degradation and the sustained release time, because of the strong interaction between CCNCs and QC chains mediated by the cross-linking agent (beta-glycerophosphate, beta-GP). The results of the in vitro toxicity and in vivo biocompatibility tests revealed that the hydrogels did :not show obvious cytotoxicity and inflammatory reaction to cells and tissue: Moreover, DOX-encapsulated hydrogels were injected beside the tumors of mice bearing liver cancer xenografts to assess the potential utility as localized and sustained drug delivery depot systems for anticancer therapy. The results suggested that the QC/CCNC/beta-GP nanocomposite hydrogels had great potential for application in subcutaneous and sustained delivery of anticancer drug to increase therapeutic efficacy and improve patient compliance.
文章类型	Article
WOS标题词	Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
DOI	10.1021/acs.biomac.6b00646
关键词[WOS]	NANOCOMPOSITE HYDROGELS ; QUATERNIZED CELLULOSE ; DRUG-DELIVERY ; POLY(ETHYLENE GLYCOL) ; REGENERATIVE MEDICINE ; SILICA NANOPARTICLE ; PROTEIN-RELEASE ; CROSS-LINKING ; TISSUE ; NANOWHISKERS
收录类别	SCI
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
项目资助者	National Natural Science Foundation of China(51473128 ; National High Technology Research and Development Program of China (863 Program)(2015AA020313) ; China Postdoctoral Science Foundation(2016M592263) ; 51273151 ; 81471789)
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Organic ; Polymer Science
WOS记录号	WOS:000383213200008
引用统计
文献类型	期刊论文
条目标识符	http://ir.qibebt.ac.cn/handle/337004/8530
专题	仿生智能材料研究组
作者单位	1.Wuhan Univ, Dept Chem, Wuhan 430072, Peoples R China 2.Wuhan Univ, Key Lab Biomed Polymers, Minist Educ, Wuhan 430072, Peoples R China 3.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, CAS Key Lab Biobased Mat, Qingdao 266101, Peoples R China 4.Wuhan Univ, Sch Basic Med Sci, Dept Biomed Engn, Wuhan 430071, Peoples R China
推荐引用方式 GB/T 7714	You, Jun,Cao, Jinfeng,Zhao, Yanteng,et al. Improved Mechanical Properties and Sustained Release Behavior of Cationic Cellulose Nanocrystals Reinforeced Cationic Cellulose Injectable Hydrogels[J]. BIOMACROMOLECULES,2016,17(9):2839-2848.
APA	You, Jun,Cao, Jinfeng,Zhao, Yanteng,Zhang, Lina,Zhou, Jinping,&Chen, Yun.(2016).Improved Mechanical Properties and Sustained Release Behavior of Cationic Cellulose Nanocrystals Reinforeced Cationic Cellulose Injectable Hydrogels.BIOMACROMOLECULES,17(9),2839-2848.
MLA	You, Jun,et al."Improved Mechanical Properties and Sustained Release Behavior of Cationic Cellulose Nanocrystals Reinforeced Cationic Cellulose Injectable Hydrogels".BIOMACROMOLECULES 17.9(2016):2839-2848.