Cytotoxicity of Postmodified Zeolitic Imidazolate Framework-90 (ZIF-90) Nanocrystals: Correlation between Functionality and Toxicity

doi:10.1002/chem.201505005

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	Cytotoxicity of Postmodified Zeolitic Imidazolate Framework-90 (ZIF-90) Nanocrystals: Correlation between Functionality and Toxicity
	Yen, Chia-I 1; Liu, Szu-Mam 2; Lo, Wei-Shang 1; Wu, Jhe-Wei 1; Liu, Yi-Hsin 1; Chein, Rong-Jie 3; Yang, Renqiang 4; Wu, Kevin C. -W.5; Hwu, Jih Ru 6,7; Ma, Nianhan 2; Shieh, Fa-Kuen 1
	2016-02-24
发表期刊	CHEMISTRY-A EUROPEAN JOURNAL
卷号	22 期号:9 页码:2925-2929
摘要	Using a simple method, the aldehyde groups of zeolitic imidazolate framework-90 (ZIF-90) nanocrystals were converted into carboxyl, amino, and thiol groups, without affecting the integrity of the framework. Notably, for the first time, correlations between functionality and cytotoxicity are also demonstrated via in vitro cytotoxicity assays. The positive charged aminated-ZIF-90 presumably results in either perturbation of cell membrane, more efficient cell uptake, or both. Therefore, the half-maximal effective (EC50) concentration of aminated-ZIF-90 has a higher cytotoxicity of about 30gmL(-1).
文章类型	Article
关键词	Cytotoxicity Drug Carriers Metal-organic Frameworks Post-modification Zif-90
WOS标题词	Science & Technology ; Physical Sciences
DOI	10.1002/chem.201505005
关键词[WOS]	METAL-ORGANIC-FRAMEWORK ; DRUG-DELIVERY ; SURFACE FUNCTIONALITY ; CELLULAR UPTAKE ; NANOPARTICLES ; CANCER ; SIZE ; SILICA ; NANOARCHITECTONICS ; CARRIERS
收录类别	SCI
语种	英语
WOS研究方向	Chemistry
项目资助者	Ministry of Science and Technology, Taiwan(MOST 104-2119M-008-010 ; 103-2320-B-008-003-MY3)
WOS类目	Chemistry, Multidisciplinary
WOS记录号	WOS:000370452300012
引用统计	被引频次：55[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qibebt.ac.cn/handle/337004/8017
专题	先进有机功能材料研究组
作者单位	1.Natl Cent Univ, Dept Chem, Taoyuan 32001, Taiwan 2.Natl Cent Univ, Inst Syst Biol & Bioinformat, Dept Biomed Sci & Engn, Taoyuan 32001, Taiwan 3.Acad Sinica, Inst Chem, Taipei 11529, Taiwan 4.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, CAS Key Lab Biobased Mat, Qingdao 266101, Peoples R China 5.Natl Taiwan Univ, Dept Chem Engn, Taipei 10617, Taiwan 6.Natl Tsing Hua Univ, Dept Chem, Hsinchu 30013, Taiwan 7.Natl Tsing Hua Univ, Frontier Res Ctr Fundamental & Appl Sci Matters, Hsinchu 30013, Taiwan
推荐引用方式 GB/T 7714	Yen, Chia-I,Liu, Szu-Mam,Lo, Wei-Shang,et al. Cytotoxicity of Postmodified Zeolitic Imidazolate Framework-90 (ZIF-90) Nanocrystals: Correlation between Functionality and Toxicity[J]. CHEMISTRY-A EUROPEAN JOURNAL,2016,22(9):2925-2929.
APA	Yen, Chia-I.,Liu, Szu-Mam.,Lo, Wei-Shang.,Wu, Jhe-Wei.,Liu, Yi-Hsin.,...&Shieh, Fa-Kuen.(2016).Cytotoxicity of Postmodified Zeolitic Imidazolate Framework-90 (ZIF-90) Nanocrystals: Correlation between Functionality and Toxicity.CHEMISTRY-A EUROPEAN JOURNAL,22(9),2925-2929.
MLA	Yen, Chia-I,et al."Cytotoxicity of Postmodified Zeolitic Imidazolate Framework-90 (ZIF-90) Nanocrystals: Correlation between Functionality and Toxicity".CHEMISTRY-A EUROPEAN JOURNAL 22.9(2016):2925-2929.