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Intestinal Microbiota Distinguish Gout Patients from Healthy Humans
Guo, Zhuang1; Zhang, Jiachao1; Wang, Zhanli3; Ang, Kay Ying2; Huang, Shi4; Hou, Qiangchuan1; Su, Xiaoquan4; Qiao, Jianmin1; Zheng, Yi1; Wang, Lifeng1; Koh, Eileen2; Ho Danliang2; Xu, Jian4; Lee, Yuan Kun2; Zhang, Heping1
2016-02-08
发表期刊SCIENTIFIC REPORTS
卷号6
摘要Current blood-based approach for gout diagnosis can be of low sensitivity and hysteretic. Here via a 68-member cohort of 33 healthy and 35 diseased individuals, we reported that the intestinal microbiota of gout patients are highly distinct from healthy individuals in both organismal and functional structures. In gout, Bacteroides caccae and Bacteroides xylanisolvens are enriched yet Faecalibacterium prausnitzii and Bifidobacterium pseudocatenulatum depleted. The established reference microbial gene catalogue for gout revealed disorder in purine degradation and butyric acid biosynthesis in gout patients. In an additional 15-member validation-group, a diagnosis model via 17 gout-associated bacteria reached 88.9% accuracy, higher than the blood-uric-acid based approach. Intestinal microbiota of gout are more similar to those of type-2 diabetes than to liver cirrhosis, whereas depletion of Faecalibacterium prausnitzii and reduced butyrate biosynthesis are shared in each of the metabolic syndromes. Thus the Microbial Index of Gout was proposed as a novel, sensitive and non-invasive strategy for diagnosing gout via fecal microbiota.
文章类型Article
WOS标题词Science & Technology
DOI10.1038/srep20602
关键词[WOS]CHRONIC KIDNEY-DISEASE ; HUMAN GUT MICROBIOME ; URIC-ACID ; SEQUENCES ; IDENTIFICATION ; HYPERURICEMIA ; ASSOCIATIONS ; POPULATION ; METAGENOME ; ALIGNMENT
收录类别SCI
语种英语
WOS研究方向Science & Technology - Other Topics
项目资助者(9870)
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000369781700001
引用统计
文献类型期刊论文
条目标识符http://ir.qibebt.ac.cn/handle/337004/7970
专题单细胞中心组群
作者单位1.Educ Minist PR China, Key Lab Dairy Biotechnol & Bioengn, Hohhot 010018, Inner Mongolia, Peoples R China
2.Natl Univ Singapore, Yong Loo Li Sch Med, Dept Microbiol, 5 Sci Dr 2, Singapore 117597, Singapore
3.Baotou Med Coll, Affiliated Hosp 1, Baotou 014010, Inner Mongolia, Peoples R China
4.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Single Cell Ctr, Qingdao 266101, Shandong, Peoples R China
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GB/T 7714
Guo, Zhuang,Zhang, Jiachao,Wang, Zhanli,et al. Intestinal Microbiota Distinguish Gout Patients from Healthy Humans[J]. SCIENTIFIC REPORTS,2016,6.
APA Guo, Zhuang.,Zhang, Jiachao.,Wang, Zhanli.,Ang, Kay Ying.,Huang, Shi.,...&Zhang, Heping.(2016).Intestinal Microbiota Distinguish Gout Patients from Healthy Humans.SCIENTIFIC REPORTS,6.
MLA Guo, Zhuang,et al."Intestinal Microbiota Distinguish Gout Patients from Healthy Humans".SCIENTIFIC REPORTS 6(2016).
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