| Metabolic engineering of Escherichia coli for biotechnological production of high-value organic acids and alcohols | |
Yu, Chao; Cao, Yujin; Zou, Huibin; Xian, Mo
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| 2011-02-01 | |
| 发表期刊 | APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
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| ISSN | 0175-7598 |
| 卷号 | 89期号:3页码:573-583 |
| 摘要 | Confronted with the gradual and inescapable exhaustion of the earth's fossil energy resources, the bio-based process to produce platform chemicals from renewable carbohydrates is attracting growing interest. Escherichia coli has been chosen as a workhouse for the production of many valuable chemicals due to its clear genetic background, convenient to be genetically modified and good growth properties with low nutrient requirements. Rational strain development of E. coli achieved by metabolic engineering strategies has provided new processes for efficiently biotechnological production of various high-value chemical building blocks. Compared to previous reviews, this review focuses on recent advances in metabolic engineering of the industrial model bacteria E. coli that lead to efficient recombinant biocatalysts for the production of high-value organic acids like succinic acid, lactic acid, 3-hydroxypropanoic acid and glucaric acid as well as alcohols like 1,3-propanediol, xylitol, mannitol, and glycerol with the discussion of the future research in this area. Besides, this review also discusses several platform chemicals, including fumaric acid, aspartic acid, glutamic acid, sorbitol, itaconic acid, and 2,5-furan dicarboxylic acid, which have not been produced by E. coli until now.; Confronted with the gradual and inescapable exhaustion of the earth's fossil energy resources, the bio-based process to produce platform chemicals from renewable carbohydrates is attracting growing interest. Escherichia coli has been chosen as a workhouse for the production of many valuable chemicals due to its clear genetic background, convenient to be genetically modified and good growth properties with low nutrient requirements. Rational strain development of E. coli achieved by metabolic engineering strategies has provided new processes for efficiently biotechnological production of various high-value chemical building blocks. Compared to previous reviews, this review focuses on recent advances in metabolic engineering of the industrial model bacteria E. coli that lead to efficient recombinant biocatalysts for the production of high-value organic acids like succinic acid, lactic acid, 3-hydroxypropanoic acid and glucaric acid as well as alcohols like 1,3-propanediol, xylitol, mannitol, and glycerol with the discussion of the future research in this area. Besides, this review also discusses several platform chemicals, including fumaric acid, aspartic acid, glutamic acid, sorbitol, itaconic acid, and 2,5-furan dicarboxylic acid, which have not been produced by E. coli until now. |
| 文章类型 | Review |
| 关键词 | Escherichia Coli Metabolic Pathway Organic Acid Alcohol Platform Chemicals |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| DOI | 10.1007/s00253-010-2970-z |
| 关键词[WOS] | WHOLE-CELL BIOTRANSFORMATION ; MINERAL SALTS MEDIUM ; D-MANNITOL FORMATION ; L-LACTIC ACID ; SUCCINATE PRODUCTION ; 3-HYDROXYPROPIONIC ACID ; XYLITOL PRODUCTION ; PHOSPHOENOLPYRUVATE CARBOXYLASE ; CORYNEBACTERIUM-GLUTAMICUM ; GLUTAMATE PRODUCTION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS研究方向 | Biotechnology & Applied Microbiology |
| WOS类目 | Biotechnology & Applied Microbiology |
| WOS记录号 | WOS:000286429400010 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qibebt.ac.cn/handle/337004/680 |
| 专题 | 生物基材料组群 |
| 作者单位 | Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Key Lab Biofuels, Qingdao 266101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Chao,Cao, Yujin,Zou, Huibin,et al. Metabolic engineering of Escherichia coli for biotechnological production of high-value organic acids and alcohols[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2011,89(3):573-583. |
| APA | Yu, Chao,Cao, Yujin,Zou, Huibin,&Xian, Mo.(2011).Metabolic engineering of Escherichia coli for biotechnological production of high-value organic acids and alcohols.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,89(3),573-583. |
| MLA | Yu, Chao,et al."Metabolic engineering of Escherichia coli for biotechnological production of high-value organic acids and alcohols".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 89.3(2011):573-583. |
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