Metabolic engineering of Escherichia coli for biotechnological production of high-value organic acids and alcohols

doi:10.1007/s00253-010-2970-z

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	Metabolic engineering of Escherichia coli for biotechnological production of high-value organic acids and alcohols
	Yu, Chao; Cao, Yujin; Zou, Huibin; Xian, Mo
	2011-02-01
发表期刊	APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
ISSN	0175-7598
卷号	89 期号:3 页码:573-583
摘要	Confronted with the gradual and inescapable exhaustion of the earth's fossil energy resources, the bio-based process to produce platform chemicals from renewable carbohydrates is attracting growing interest. Escherichia coli has been chosen as a workhouse for the production of many valuable chemicals due to its clear genetic background, convenient to be genetically modified and good growth properties with low nutrient requirements. Rational strain development of E. coli achieved by metabolic engineering strategies has provided new processes for efficiently biotechnological production of various high-value chemical building blocks. Compared to previous reviews, this review focuses on recent advances in metabolic engineering of the industrial model bacteria E. coli that lead to efficient recombinant biocatalysts for the production of high-value organic acids like succinic acid, lactic acid, 3-hydroxypropanoic acid and glucaric acid as well as alcohols like 1,3-propanediol, xylitol, mannitol, and glycerol with the discussion of the future research in this area. Besides, this review also discusses several platform chemicals, including fumaric acid, aspartic acid, glutamic acid, sorbitol, itaconic acid, and 2,5-furan dicarboxylic acid, which have not been produced by E. coli until now.; Confronted with the gradual and inescapable exhaustion of the earth's fossil energy resources, the bio-based process to produce platform chemicals from renewable carbohydrates is attracting growing interest. Escherichia coli has been chosen as a workhouse for the production of many valuable chemicals due to its clear genetic background, convenient to be genetically modified and good growth properties with low nutrient requirements. Rational strain development of E. coli achieved by metabolic engineering strategies has provided new processes for efficiently biotechnological production of various high-value chemical building blocks. Compared to previous reviews, this review focuses on recent advances in metabolic engineering of the industrial model bacteria E. coli that lead to efficient recombinant biocatalysts for the production of high-value organic acids like succinic acid, lactic acid, 3-hydroxypropanoic acid and glucaric acid as well as alcohols like 1,3-propanediol, xylitol, mannitol, and glycerol with the discussion of the future research in this area. Besides, this review also discusses several platform chemicals, including fumaric acid, aspartic acid, glutamic acid, sorbitol, itaconic acid, and 2,5-furan dicarboxylic acid, which have not been produced by E. coli until now.
文章类型	Review
关键词	Escherichia Coli Metabolic Pathway Organic Acid Alcohol Platform Chemicals
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
DOI	10.1007/s00253-010-2970-z
关键词[WOS]	WHOLE-CELL BIOTRANSFORMATION ; MINERAL SALTS MEDIUM ; D-MANNITOL FORMATION ; L-LACTIC ACID ; SUCCINATE PRODUCTION ; 3-HYDROXYPROPIONIC ACID ; XYLITOL PRODUCTION ; PHOSPHOENOLPYRUVATE CARBOXYLASE ; CORYNEBACTERIUM-GLUTAMICUM ; GLUTAMATE PRODUCTION
收录类别	SCI
语种	英语
WOS研究方向	Biotechnology & Applied Microbiology
WOS类目	Biotechnology & Applied Microbiology
WOS记录号	WOS:000286429400010
引用统计
文献类型	期刊论文
条目标识符	http://ir.qibebt.ac.cn/handle/337004/680
专题	生物基材料组群
作者单位	Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Key Lab Biofuels, Qingdao 266101, Peoples R China
推荐引用方式 GB/T 7714	Yu, Chao,Cao, Yujin,Zou, Huibin,et al. Metabolic engineering of Escherichia coli for biotechnological production of high-value organic acids and alcohols[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2011,89(3):573-583.
APA	Yu, Chao,Cao, Yujin,Zou, Huibin,&Xian, Mo.(2011).Metabolic engineering of Escherichia coli for biotechnological production of high-value organic acids and alcohols.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,89(3),573-583.
MLA	Yu, Chao,et al."Metabolic engineering of Escherichia coli for biotechnological production of high-value organic acids and alcohols".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 89.3(2011):573-583.

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