Protein-protein complexation in bioluminescence

doi:10.1007/s13238-011-1118-y

QIBEBT-IR > 代谢物组学研究组

	Protein-protein complexation in bioluminescence
	Titushin, Maxim S.1; Feng, Yingang2 ; Lee, John 3; Vysotski, Eugene S.4; Liu, Zhi-Jie 1
	2011-12-01
发表期刊	PROTEIN & CELL
卷号	2 期号:12 页码:957-972
摘要	In this review we summarize the progress made towards understanding the role of protein-protein interactions in the function of various bioluminescence systems of marine organisms, including bacteria, jellyfish and soft corals, with particular focus on methodology used to detect and characterize these interactions. In some bioluminescence systems, protein-protein interactions involve an "accessory protein" whereby a stored substrate is efficiently delivered to the bioluminescent enzyme luciferase. Other types of complexation mediate energy transfer to an "antenna protein" altering the color and quantum yield of a bioluminescence reaction. Spatial structures of the complexes reveal an important role of electrostatic forces in governing the corresponding weak interactions and define the nature of the interaction surfaces. The most reliable structural model is available for the protein-protein complex of the Ca2+-regulated photoprotein clytin and green-fluorescent protein (GFP) from the jellyfish Clytia gregaria, solved by means of X-ray crystallography, NMR mapping and molecular docking. This provides an example of the potential strategies in studying the transient complexes involved in bioluminescence. It is emphasized that structural studies such as these can provide valuable insight into the detailed mechanism of bioluminescence.
文章类型	Review
关键词	Green-fluorescent Protein (Gfp) Photoprotein Luciferase Lumazine Protein Forster Resonance Energy Transfer (Fret) Docking
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
DOI	10.1007/s13238-011-1118-y
关键词[WOS]	GREEN-FLUORESCENT PROTEIN ; LUCIFERIN-BINDING-PROTEIN ; RENILLA-RENIFORMIS LUCIFERASE ; VIBRIO-FISCHERI Y1 ; JELLYFISH CLYTIA-GREGARIA ; ALPHA/BETA-HYDROLASE FOLD ; AMINO-ACID-SEQUENCE ; BACTERIAL LUCIFERASE ; ENERGY-TRANSFER ; CRYSTAL-STRUCTURE
收录类别	SCI
语种	英语
WOS研究方向	Cell Biology
WOS类目	Cell Biology
WOS记录号	WOS:000310522900005
引用统计	被引频次：16[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qibebt.ac.cn/handle/337004/6641
专题	代谢物组学研究组
作者单位	1.Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao 266101, Peoples R China 3.Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA 4.Russian Acad Sci, Siberian Branch, Inst Biophys, Lab Photobiol, Krasnoyarsk 660036, Russia
推荐引用方式 GB/T 7714	Titushin, Maxim S.,Feng, Yingang,Lee, John,et al. Protein-protein complexation in bioluminescence[J]. PROTEIN & CELL,2011,2(12):957-972.
APA	Titushin, Maxim S.,Feng, Yingang,Lee, John,Vysotski, Eugene S.,&Liu, Zhi-Jie.(2011).Protein-protein complexation in bioluminescence.PROTEIN & CELL,2(12),957-972.
MLA	Titushin, Maxim S.,et al."Protein-protein complexation in bioluminescence".PROTEIN & CELL 2.12(2011):957-972.