| Recent Development of Nano-Materials Used in DNA Biosensors | |
| Xu, Kai1,2,3; Huang, Junran1; Ye, Zunzhong1; Ying, Yibin1; Li, Yanbin4 | |
| 2009-07-01 | |
| 发表期刊 | SENSORS
 |
| 卷号 | 9期号:7页码:5534-5557 |
| 摘要 | As knowledge of the structure and function of nucleic acid molecules has increased, sequence-specific DNA detection has gained increased importance. DNA biosensors based on nucleic acid hybridization have been actively developed because of their specificity, speed, portability, and low cost. Recently, there has been considerable interest in using nano-materials for DNA biosensors. Because of their high surface-to-volume ratios and excellent biological compatibilities, nano-materials could be used to increase the amount of DNA immobilization; moreover, DNA bound to nano-materials can maintain its biological activity. Alternatively, signal amplification by labeling a targeted analyte with nano-materials has also been reported for DNA biosensors in many papers. This review summarizes the applications of various nano-materials for DNA biosensors during past five years. We found that nano-materials of small sizes were advantageous as substrates for DNA attachment or as labels for signal amplification; and use of two or more types of nano-materials in the biosensors could improve their overall quality and to overcome the deficiencies of the individual nano-components. Most current DNA biosensors require the use of polymerase chain reaction (PCR) in their protocols. However, further development of nano-materials with smaller size and/or with improved biological and chemical properties would substantially enhance the accuracy, selectivity and sensitivity of DNA biosensors. Thus, DNA biosensors without PCR amplification may become a reality in the foreseeable future. |
| 文章类型 | Review |
| 关键词 | Nano-material Dna Biosensor Substrates Signal Amplification |
| WOS标题词 | Science & Technology ; Physical Sciences ; Technology |
| DOI | 10.3390/s90705534 |
| 关键词[WOS] | WALLED CARBON NANOTUBES ; ELECTROGENERATED CHEMILUMINESCENCE DETECTION ; ELECTROCHEMICAL STRIPPING DETECTION ; NANOPARTICLE SIGNAL AMPLIFICATION ; GENETICALLY-MODIFIED ORGANISMS ; CONDUCTING POLYMER-FILM ; CALF THYMUS DNA ; GOLD NANOPARTICLES ; MODIFIED ELECTRODE ; VOLTAMMETRIC DETECTION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS研究方向 | Chemistry ; Electrochemistry ; Instruments & Instrumentation |
| WOS类目 | Chemistry, Analytical ; Electrochemistry ; Instruments & Instrumentation |
| WOS记录号 | WOS:000268317000028 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qibebt.ac.cn/handle/337004/6631 |
| 专题 | 公共实验室 |
| 作者单位 | 1.Zhejiang Univ, Sch Biosyst Engn & Food Sci, Hangzhou 310029, Zhejiang, Peoples R China 2.Chinese Acad Sci, Key Lab Biofuels, Qingdao 266101, Shandong, Peoples R China 3.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao 266101, Shandong, Peoples R China 4.Univ Arkansas, Dept Biol & Agr Engn, Fayetteville, AR 72701 USA |
| 推荐引用方式 GB/T 7714 | Xu, Kai,Huang, Junran,Ye, Zunzhong,et al. Recent Development of Nano-Materials Used in DNA Biosensors[J]. SENSORS,2009,9(7):5534-5557. |
| APA | Xu, Kai,Huang, Junran,Ye, Zunzhong,Ying, Yibin,&Li, Yanbin.(2009).Recent Development of Nano-Materials Used in DNA Biosensors.SENSORS,9(7),5534-5557. |
| MLA | Xu, Kai,et al."Recent Development of Nano-Materials Used in DNA Biosensors".SENSORS 9.7(2009):5534-5557. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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