Investigation of the Electrochemical Interaction Behavior of DNA with 5-Fluorouracil Derivatives

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	Investigation of the Electrochemical Interaction Behavior of DNA with 5-Fluorouracil Derivatives
	Zhang, Ke-jun 1,2; Liu, Wu-yi 1
	2011-05-01
发表期刊	INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE
卷号	6 期号:5 页码:1669-1678
摘要	Although many 5-Fluorouracil derivatives have been synthesized and identified, there are few reports on the interaction modes of different anti-carcinogen 5-Fluorouracil derivatives with Deoxyribonucleic acid (DNA). In this study, five new anti-carcinogen 5-Fluorouracil derivatives with DNA were investigated, i.e. 5-FU-Asp, 5-Fu-Trp, 5-FU-Ser, 5-FU-Tyr, and 5-FU-Phe, and their DNA binding specificities were compared by electrochemical means with previous reported DNA ligands. Meanwhile, the cyclic voltammetry has been proved to be powerful for the elucidation of interactions between DNA and 5-Fluorouracil derivatives, with Fe(CN)(6)(3-/4-) as electroactive indicator of the intercalative interaction dominance. Using this electrochemical approach and Deoxyribonucleic acid (DNA) modified gold electrodes prepared by the dry adsorptive method, the electrochemical behaviors and modes of 5-Fluorouracil derivatives targeting DNA were well studied. The binding of 5-Fluorouracil derivatives with DNA, analyzed in terms of the cooperative Hill model, yields different association constants and binding numbers. This study serves as a good reference for synthesis, structural characterization of novel 5-Fluorouracil derivatives.
文章类型	Article
关键词	Dna Anti-carcinogen Derivative Of 5-fluorouracil Intercalation Cyclic Voltammetry
WOS标题词	Science & Technology ; Physical Sciences
关键词[WOS]	CRYSTAL-STRUCTURE ; OLIGONUCLEOTIDES ; LANTHANIDES ; SEPARATION ; ACTINIDES ; COMPLEX ; CHAIN
收录类别	SCI
语种	英语
WOS研究方向	Electrochemistry
WOS类目	Electrochemistry
WOS记录号	WOS:000290097000034
引用统计
文献类型	期刊论文
条目标识符	http://ir.qibebt.ac.cn/handle/337004/6546
专题	仿生与固态能源系统研究组
作者单位	1.Fuyang Normal Coll, Dept Biol Sci, Fuyang City 236041, Peoples R China 2.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Ke-jun,Liu, Wu-yi. Investigation of the Electrochemical Interaction Behavior of DNA with 5-Fluorouracil Derivatives[J]. INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE,2011,6(5):1669-1678.
APA	Zhang, Ke-jun,&Liu, Wu-yi.(2011).Investigation of the Electrochemical Interaction Behavior of DNA with 5-Fluorouracil Derivatives.INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE,6(5),1669-1678.
MLA	Zhang, Ke-jun,et al."Investigation of the Electrochemical Interaction Behavior of DNA with 5-Fluorouracil Derivatives".INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE 6.5(2011):1669-1678.