Highly brominated metabolites from marine red alga Laurencia similis inhibit protein tyrosine phosphatase 1B

doi:10.1016/j.bmcl.2010.08.144

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	Highly brominated metabolites from marine red alga Laurencia similis inhibit protein tyrosine phosphatase 1B
	Qin, Jianchun 1; Su, Hua2 ; Zhang, Yamei 1; Gao, Jinming 3; Zhu, Lin 1; Wu, Xian 1; Pan, Hongyu 1; Li, Xiang 1,4
	2010-12-01
发表期刊	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷号	20 期号:23 页码:7152-7154
摘要	Five new highly brominated metabolites, 3',5',6',6-tetrabromo-2,4-dimethyldiphenyl ether (1), 1,2,5-tribromo-3-bromoamino-7-bromomethylnaphthalene (2), 2,5,8-tribromo-3-bromoamino-7-bromomethylnaphthalene (3), 2,5,6-tribromo-3-bromoamino-7-bromomethylnaphthalene (4) and 2',5',6',5, 6-pentabromo-3',4',3,4-tetramethoxybenzo-phenone (5) were isolated from the red alga Laurencia similis. Their structures were elucidated by spectroscopic methods including one-and two-dimensional NMR as well as HREIMS analysis. Compounds 1 and 5 showed strong inhibitory activities against protein tyrosine phosphatase 1B (PTP1B) with IC(50) of 2.97 and 2.66 mu M, respectively. (C) 2010 Elsevier Ltd. All rights reserved.
文章类型	Article
关键词	Brominated Metabolites Laurencia Similis Protein Tyrosine Phosphatase 1b
WOS标题词	Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
DOI	10.1016/j.bmcl.2010.08.144
关键词[WOS]	ARISTOLANE SESQUITERPENES ; RHODOMELACEAE
收录类别	SCI
语种	英语
WOS研究方向	Pharmacology & Pharmacy ; Chemistry
WOS类目	Chemistry, Medicinal ; Chemistry, Organic
WOS记录号	WOS:000283801400059
引用统计
文献类型	期刊论文
条目标识符	http://ir.qibebt.ac.cn/handle/337004/6533
专题	人事教育处
作者单位	1.Jilin Univ, Coll Plant Sci, Changchun 130062, Peoples R China 2.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao 266101, Peoples R China 3.NW A&F Univ, Nat Med Chem Res Ctr, Coll Sci, Yangling 712100, Peoples R China 4.Agr & Agri Food Canada, Saskatoon, SK S7N 0X2, Canada
推荐引用方式 GB/T 7714	Qin, Jianchun,Su, Hua,Zhang, Yamei,et al. Highly brominated metabolites from marine red alga Laurencia similis inhibit protein tyrosine phosphatase 1B[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2010,20(23):7152-7154.
APA	Qin, Jianchun.,Su, Hua.,Zhang, Yamei.,Gao, Jinming.,Zhu, Lin.,...&Li, Xiang.(2010).Highly brominated metabolites from marine red alga Laurencia similis inhibit protein tyrosine phosphatase 1B.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,20(23),7152-7154.
MLA	Qin, Jianchun,et al."Highly brominated metabolites from marine red alga Laurencia similis inhibit protein tyrosine phosphatase 1B".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 20.23(2010):7152-7154.