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Cellulosome stoichiometry in Clostridium cellulolyticum is regulated by selective RNA processing and stabilization
Xu, Chenggang1,2,3; Huang, Ranran1,2,3,4; Teng, Lin1,2,3,4; Jing, Xiaoyan1,2,3; Hu, Jianqiang1,2,3,4; Cui, Guzhen2,3; Wang, Yilin1,2,3,4; Cui, Qiu2,3; Xu, Jian1,2,3
2015-04-01
Source PublicationNATURE COMMUNICATIONS
Volume6
AbstractThe mechanism, physiological relevance and evolutionary implication of selective RNA processing and stabilization (SRPS) remain elusive. Here we report the genome-wide maps of transcriptional start sites (TSs) and post-transcriptional processed sites (PSs) for Clostridium cellulolyticum. The PS-associated genes are preferably associated with subunits of heteromultimeric protein complexes, and the intergenic PSs (iPSs) are enriched in operons exhibiting highly skewed transcript-abundance landscape. Stem-loop structures associated with those iPSs located at 3' termini of highly transcribed genes exhibit folding free energy negatively correlated with transcript-abundance ratio of flanking genes. In the cellulosome-encoding cip-cel operon, iPSs and stem-loops precisely regulate structure and abundance of the subunit-encoding transcripts processed from a primary polycistronic RNA, quantitatively specifying cellulosome stoichiometry. Moreover, cellulosome evolution is shaped by the number, position and biophysical nature of TSs, iPSs and stem-loops. Our findings unveil a genome-wide RNA-encoded strategy controlling in vivo stoichiometry of protein complexes.
SubtypeArticle
WOS HeadingsScience & Technology
DOI10.1038/ncomms7900
WOS KeywordRELATIVE GENE-EXPRESSION ; MESSENGER-RNA ; ESCHERICHIA-COLI ; BACILLUS-SUBTILIS ; PHOTOSYNTHESIS GENES ; DIFFERENTIAL DECAY ; OPERON ; DEGRADATION ; TRANSCRIPTION ; STABILITY
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000353704100008
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qibebt.ac.cn/handle/337004/6444
Collection单细胞中心组群
Affiliation1.Chinese Acad Sci, Single Cell Ctr, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao 266101, Shandong, Peoples R China
2.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Key Lab Biofuels, Qingdao 266101, Shandong, Peoples R China
3.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Shandong Key Lab Energy Genet, Qingdao 266101, Shandong, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Xu, Chenggang,Huang, Ranran,Teng, Lin,et al. Cellulosome stoichiometry in Clostridium cellulolyticum is regulated by selective RNA processing and stabilization[J]. NATURE COMMUNICATIONS,2015,6.
APA Xu, Chenggang.,Huang, Ranran.,Teng, Lin.,Jing, Xiaoyan.,Hu, Jianqiang.,...&Xu, Jian.(2015).Cellulosome stoichiometry in Clostridium cellulolyticum is regulated by selective RNA processing and stabilization.NATURE COMMUNICATIONS,6.
MLA Xu, Chenggang,et al."Cellulosome stoichiometry in Clostridium cellulolyticum is regulated by selective RNA processing and stabilization".NATURE COMMUNICATIONS 6(2015).
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