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Cellulosome stoichiometry in Clostridium cellulolyticum is regulated by selective RNA processing and stabilization
Xu, Chenggang1,2,3; Huang, Ranran1,2,3,4; Teng, Lin1,2,3,4; Jing, Xiaoyan1,2,3; Hu, Jianqiang1,2,3,4; Cui, Guzhen2,3; Wang, Yilin1,2,3,4; Cui, Qiu2,3; Xu, Jian1,2,3
2015-04-01
发表期刊NATURE COMMUNICATIONS
卷号6
摘要The mechanism, physiological relevance and evolutionary implication of selective RNA processing and stabilization (SRPS) remain elusive. Here we report the genome-wide maps of transcriptional start sites (TSs) and post-transcriptional processed sites (PSs) for Clostridium cellulolyticum. The PS-associated genes are preferably associated with subunits of heteromultimeric protein complexes, and the intergenic PSs (iPSs) are enriched in operons exhibiting highly skewed transcript-abundance landscape. Stem-loop structures associated with those iPSs located at 3' termini of highly transcribed genes exhibit folding free energy negatively correlated with transcript-abundance ratio of flanking genes. In the cellulosome-encoding cip-cel operon, iPSs and stem-loops precisely regulate structure and abundance of the subunit-encoding transcripts processed from a primary polycistronic RNA, quantitatively specifying cellulosome stoichiometry. Moreover, cellulosome evolution is shaped by the number, position and biophysical nature of TSs, iPSs and stem-loops. Our findings unveil a genome-wide RNA-encoded strategy controlling in vivo stoichiometry of protein complexes.
文章类型Article
WOS标题词Science & Technology
DOI10.1038/ncomms7900
关键词[WOS]RELATIVE GENE-EXPRESSION ; MESSENGER-RNA ; ESCHERICHIA-COLI ; BACILLUS-SUBTILIS ; PHOTOSYNTHESIS GENES ; DIFFERENTIAL DECAY ; OPERON ; DEGRADATION ; TRANSCRIPTION ; STABILITY
收录类别SCI
语种英语
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000353704100008
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qibebt.ac.cn/handle/337004/6444
专题单细胞中心
作者单位1.Chinese Acad Sci, Single Cell Ctr, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao 266101, Shandong, Peoples R China
2.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Key Lab Biofuels, Qingdao 266101, Shandong, Peoples R China
3.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Shandong Key Lab Energy Genet, Qingdao 266101, Shandong, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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GB/T 7714
Xu, Chenggang,Huang, Ranran,Teng, Lin,et al. Cellulosome stoichiometry in Clostridium cellulolyticum is regulated by selective RNA processing and stabilization[J]. NATURE COMMUNICATIONS,2015,6.
APA Xu, Chenggang.,Huang, Ranran.,Teng, Lin.,Jing, Xiaoyan.,Hu, Jianqiang.,...&Xu, Jian.(2015).Cellulosome stoichiometry in Clostridium cellulolyticum is regulated by selective RNA processing and stabilization.NATURE COMMUNICATIONS,6.
MLA Xu, Chenggang,et al."Cellulosome stoichiometry in Clostridium cellulolyticum is regulated by selective RNA processing and stabilization".NATURE COMMUNICATIONS 6(2015).
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