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Title:
Cellulosome stoichiometry in Clostridium cellulolyticum is regulated by selective RNA processing and stabilization
Author: Xu, Chenggang1,2,3; Huang, Ranran1,2,3,4; Teng, Lin1,2,3,4; Jing, Xiaoyan1,2,3; Hu, Jianqiang1,2,3,4; Cui, Guzhen2,3; Wang, Yilin1,2,3,4; Cui, Qiu2,3; Xu Jian(徐健)1,2,3
Source: NATURE COMMUNICATIONS
Issued Date: 2015-04-01
Volume: 6
DOI: 10.1038/ncomms7900
DOC Type: Article
English Abstract: The mechanism, physiological relevance and evolutionary implication of selective RNA processing and stabilization (SRPS) remain elusive. Here we report the genome-wide maps of transcriptional start sites (TSs) and post-transcriptional processed sites (PSs) for Clostridium cellulolyticum. The PS-associated genes are preferably associated with subunits of heteromultimeric protein complexes, and the intergenic PSs (iPSs) are enriched in operons exhibiting highly skewed transcript-abundance landscape. Stem-loop structures associated with those iPSs located at 3' termini of highly transcribed genes exhibit folding free energy negatively correlated with transcript-abundance ratio of flanking genes. In the cellulosome-encoding cip-cel operon, iPSs and stem-loops precisely regulate structure and abundance of the subunit-encoding transcripts processed from a primary polycistronic RNA, quantitatively specifying cellulosome stoichiometry. Moreover, cellulosome evolution is shaped by the number, position and biophysical nature of TSs, iPSs and stem-loops. Our findings unveil a genome-wide RNA-encoded strategy controlling in vivo stoichiometry of protein complexes.
WOS Headings: Science & Technology
WOS Subject: Multidisciplinary Sciences
WOS Subject Extended: Science & Technology - Other Topics
WOS Keyword Plus: RELATIVE GENE-EXPRESSION ; MESSENGER-RNA ; ESCHERICHIA-COLI ; BACILLUS-SUBTILIS ; PHOTOSYNTHESIS GENES ; DIFFERENTIAL DECAY ; OPERON ; DEGRADATION ; TRANSCRIPTION ; STABILITY
Indexed Type: SCI
Language: 英语
WOS ID: WOS:000353704100008
Citation statistics:
Content Type: 期刊论文
URI: http://ir.qibebt.ac.cn/handle/337004/6444
Appears in Collections:单细胞中心_期刊论文

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description.institution: 1.Chinese Acad Sci, Single Cell Ctr, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao 266101, Shandong, Peoples R China
2.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Key Lab Biofuels, Qingdao 266101, Shandong, Peoples R China
3.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Shandong Key Lab Energy Genet, Qingdao 266101, Shandong, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China

Recommended Citation:
Xu, Chenggang,Huang, Ranran,Teng, Lin,et al. Cellulosome stoichiometry in Clostridium cellulolyticum is regulated by selective RNA processing and stabilization[J]. NATURE COMMUNICATIONS,2015,6.
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