The stat3/socs3a Pathway Is a Key Regulator of Hair Cell Regeneration in Zebrafish stat3/socs3a Pathway: Regulator of Hair Cell Regeneration

doi:10.1523/JNEUROSCI.5785-10.2012

QIBEBT-IR > 单细胞中心组群

	The stat3/socs3a Pathway Is a Key Regulator of Hair Cell Regeneration in Zebrafish stat3/socs3a Pathway: Regulator of Hair Cell Regeneration
	Liang, Jin 1,2,3; Wang, Dongmei4 ; Renaud, Gabriel 1,2; Wolfsberg, Tyra G.1,2; Wilson, Alexander F.; Burgess, Shawn M.1,2
	2012-08-01
发表期刊	JOURNAL OF NEUROSCIENCE
卷号	32 期号:31 页码:10662-10673
摘要	All nonmammalian vertebrates studied can regenerate inner ear mechanosensory receptors (i.e., hair cells) (Corwin and Cotanche, 1988; Lombarte et al., 1993; Baird et al., 1996), but mammals possess only a very limited capacity for regeneration after birth (Roberson and Rubel, 1994). As a result, mammals experience permanent deficiencies in hearing and balance once their inner ear hair cells are lost. The mechanisms of hair cell regeneration are poorly understood. Because the inner ear sensory epithelium is highly conserved in all vertebrates (Fritzsch et al., 2007), we chose to study hair cell regeneration mechanism in adult zebrafish, hoping the results would be transferrable to inducing hair cell regeneration in mammals. We defined the comprehensive network of genes involved in hair cell regeneration in the inner ear of adult zebrafish with the powerful transcriptional profiling technique digital gene expression, which leverages the power of next-generation sequencing ('t Hoen et al., 2008). We also identified a key pathway, stat3/socs3, and demonstrated its role in promoting hair cell regeneration through stem cell activation, cell division, and differentiation. In addition, transient pharmacological inhibition of stat3 signaling accelerated hair cell regeneration without overproducing cells. Taking other published datasets into account (Sano et al., 1999; Schebesta et al., 2006; Dierssen et al., 2008; Riehle et al., 2008; Zhu et al., 2008; Qin et al., 2009), we propose that the stat3/socs3 pathway is a key response in all tissue regeneration and thus an important therapeutic target for a broad application in tissue repair and injury healing.
文章类型	Article
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
DOI	10.1523/JNEUROSCI.5785-10.2012
关键词[WOS]	LATERAL-LINE SYSTEM ; INNER-EAR ; LIVER-REGENERATION ; DANIO-RERIO ; SERINE PHOSPHORYLATION ; SIGNAL TRANSDUCER ; COCHLEAR CHANGES ; ACOUSTIC TRAUMA ; LASER-ABLATION ; HEARING-LOSS
收录类别	SCI
语种	英语
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000307125900023
引用统计
文献类型	期刊论文
条目标识符	http://ir.qibebt.ac.cn/handle/337004/6349
专题	单细胞中心组群
作者单位	1.NHGRI, Genome Technol Branch, Bethesda, MD 20892 USA 2.NHGRI, Inherited Dis Res Branch, Bethesda, MD 20892 USA 3.Univ Maryland, Neurosci & Cognit Sci Program, College Pk, MD 20742 USA 4.Chinese Acad Sci, Qingdao Inst BioEnergy & BioProcess Technol, Qingdao 266101, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Liang, Jin,Wang, Dongmei,Renaud, Gabriel,et al. The stat3/socs3a Pathway Is a Key Regulator of Hair Cell Regeneration in Zebrafish stat3/socs3a Pathway: Regulator of Hair Cell Regeneration[J]. JOURNAL OF NEUROSCIENCE,2012,32(31):10662-10673.
APA	Liang, Jin,Wang, Dongmei,Renaud, Gabriel,Wolfsberg, Tyra G.,Wilson, Alexander F.,&Burgess, Shawn M..(2012).The stat3/socs3a Pathway Is a Key Regulator of Hair Cell Regeneration in Zebrafish stat3/socs3a Pathway: Regulator of Hair Cell Regeneration.JOURNAL OF NEUROSCIENCE,32(31),10662-10673.
MLA	Liang, Jin,et al."The stat3/socs3a Pathway Is a Key Regulator of Hair Cell Regeneration in Zebrafish stat3/socs3a Pathway: Regulator of Hair Cell Regeneration".JOURNAL OF NEUROSCIENCE 32.31(2012):10662-10673.