The Archaeal Sac10b Protein Family: Conserved Proteins with Divergent Functions

QIBEBT-IR > 代谢物组学研究组

	The Archaeal Sac10b Protein Family: Conserved Proteins with Divergent Functions
	Xuan, Jinsong 1; Feng, Yingang2,3
	2012-05-01
发表期刊	CURRENT PROTEIN & PEPTIDE SCIENCE
卷号	13 期号:3 页码:258-266
摘要	Here we review the present state of structural and functional studies of the Sac10b protein family, a class of highly conserved 10 kDa nucleic acid-binding proteins in archaea. Based on biochemical and structural studies, these proteins were originally assigned a role in the structural organization of chromatin; Sac10b proteins of hyperthermophilic archaea, for example, showed tight, unspecific DNA binding. More recently, however, Sac10b proteins of mesophilic archaea were found to interact preferentially with specific DNA sequences thereby affecting the expression of distinct genes. Furthermore, Sac10b proteins of hyperthermophilic, thermophilic and mesophilic archaea were also shown to bind to RNA with distinct affinities and specificities but functional consequences of RNA binding of these proteins, besides perhaps RNA stabilization, have not yet been observed. To better understand the physiological meaning of the various interactions of Sac10b proteins with nucleic acids, future work should concentrate on elucidating the molecular structures of complexes of Sac10b proteins of hyperthermophilic and mesophilic archaea with DNA and RNA. In addition, existing and new X-ray and NMR structures of individual hyperthermophilic Sac10b proteins may represent very good models for introducing thermostability especially in enzymes for industrial use.
文章类型	Review
关键词	Archaea Sac10b Protein Family X-ray And Nmr Structures Dna- And Rna-binding Proteins Functional Diversity
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]	DNA-BINDING PROTEIN ; ARCHAEBACTERIUM SULFOLOBUS-ACIDOCALDARIUS ; NUCLEIC-ACID BINDING ; CHROMATIN PROTEIN ; CRYSTAL-STRUCTURE ; HYPERTHERMOPHILIC ARCHAEAL ; MICROSEQUENCE ANALYSIS ; METHANOCOCCUS-VOLTAE ; ALBA ; STABILITY
收录类别	SCI
语种	英语
WOS研究方向	Biochemistry & Molecular Biology
WOS类目	Biochemistry & Molecular Biology
WOS记录号	WOS:000304597300006
引用统计	被引频次：10[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qibebt.ac.cn/handle/337004/6334
专题	代谢物组学研究组
作者单位	1.Univ Sci & Technol Beijing, Dept Biol Sci & Engn, Sch Chem & Biol Engn, Beijing 100083, Peoples R China 2.Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao 266101, Peoples R China
推荐引用方式 GB/T 7714	Xuan, Jinsong,Feng, Yingang. The Archaeal Sac10b Protein Family: Conserved Proteins with Divergent Functions[J]. CURRENT PROTEIN & PEPTIDE SCIENCE,2012,13(3):258-266.
APA	Xuan, Jinsong,&Feng, Yingang.(2012).The Archaeal Sac10b Protein Family: Conserved Proteins with Divergent Functions.CURRENT PROTEIN & PEPTIDE SCIENCE,13(3),258-266.
MLA	Xuan, Jinsong,et al."The Archaeal Sac10b Protein Family: Conserved Proteins with Divergent Functions".CURRENT PROTEIN & PEPTIDE SCIENCE 13.3(2012):258-266.