QIBEBT-IR  > 单细胞中心组群
Saliva Microbiota Carry Caries-Specific Functional Gene Signatures
Yang, Fang1; Ning, Kang2,3; Chang, Xingzhi2,3; Yuan, Xiao1; Tu, Qichao4; Yuan, Tong4; Deng, Ye4; Hemme, Christopher L.4; Van Nostrand, Joy4; Cui, Xinping5; He, Zhili4; Chen, Zhenggang1; Guo, Dawei1; Yu, Jiangbo1; Zhang, Yue1; Zhou, Jizhong4; Xu, Jian2,3
Source PublicationPLOS ONE
AbstractHuman saliva microbiota is phylogenetically divergent among host individuals yet their roles in health and disease are poorly appreciated. We employed a microbial functional gene microarray, HuMiChip 1.0, to reconstruct the global functional profiles of human saliva microbiota from ten healthy and ten caries-active adults. Saliva microbiota in the pilot population featured a vast diversity of functional genes. No significant distinction in gene number or diversity indices was observed between healthy and caries-active microbiota. However, co-presence network analysis of functional genes revealed that caries-active microbiota was more divergent in non-core genes than healthy microbiota, despite both groups exhibited a similar degree of conservation at their respective core genes. Furthermore, functional gene structure of saliva microbiota could potentially distinguish caries-active patients from healthy hosts. Microbial functions such as Diaminopimelate epimerase, Prephenate dehydrogenase, Pyruvate-formate lyase and N-acetylmuramoyl-L-alanine amidase were significantly linked to caries. Therefore, saliva microbiota carried disease-associated functional signatures, which could be potentially exploited for caries diagnosis.
WOS HeadingsScience & Technology
Indexed BySCI
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000331262600001
Citation statistics
Cited Times:50[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Affiliation1.Qingdao Municipal Hosp, Oral Res Ctr, Qingdao, Shandong, Peoples R China
2.Chinese Acad Sci, CAS Key Lab Biofuels, Shandong Key Lab Energy Genet, Qingdao, Shandong, Peoples R China
3.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, BioEnergy Genome Ctr, Qingdao, Shandong, Peoples R China
4.Univ Oklahoma, Inst Environm Genom, Norman, OK 73019 USA
5.Univ Calif Riverside, Dept Stat, Riverside, CA 92521 USA
Recommended Citation
GB/T 7714
Yang, Fang,Ning, Kang,Chang, Xingzhi,et al. Saliva Microbiota Carry Caries-Specific Functional Gene Signatures[J]. PLOS ONE,2014,9(2).
APA Yang, Fang.,Ning, Kang.,Chang, Xingzhi.,Yuan, Xiao.,Tu, Qichao.,...&Xu, Jian.(2014).Saliva Microbiota Carry Caries-Specific Functional Gene Signatures.PLOS ONE,9(2).
MLA Yang, Fang,et al."Saliva Microbiota Carry Caries-Specific Functional Gene Signatures".PLOS ONE 9.2(2014).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Yang, Fang]'s Articles
[Ning, Kang]'s Articles
[Chang, Xingzhi]'s Articles
Baidu academic
Similar articles in Baidu academic
[Yang, Fang]'s Articles
[Ning, Kang]'s Articles
[Chang, Xingzhi]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yang, Fang]'s Articles
[Ning, Kang]'s Articles
[Chang, Xingzhi]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.