| Saliva Microbiota Carry Caries-Specific Functional Gene Signatures | |
Yang, Fang1; Ning, Kang2,3; Chang, Xingzhi2,3; Yuan, Xiao1; Tu, Qichao4; Yuan, Tong4; Deng, Ye4; Hemme, Christopher L.4; Van Nostrand, Joy4; Cui, Xinping5; He, Zhili4; Chen, Zhenggang1; Guo, Dawei1; Yu, Jiangbo1; Zhang, Yue1; Zhou, Jizhong4; Xu, Jian2,3
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| 2014-02-12 | |
| 发表期刊 | PLOS ONE
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| 卷号 | 9期号:2 |
| 摘要 | Human saliva microbiota is phylogenetically divergent among host individuals yet their roles in health and disease are poorly appreciated. We employed a microbial functional gene microarray, HuMiChip 1.0, to reconstruct the global functional profiles of human saliva microbiota from ten healthy and ten caries-active adults. Saliva microbiota in the pilot population featured a vast diversity of functional genes. No significant distinction in gene number or diversity indices was observed between healthy and caries-active microbiota. However, co-presence network analysis of functional genes revealed that caries-active microbiota was more divergent in non-core genes than healthy microbiota, despite both groups exhibited a similar degree of conservation at their respective core genes. Furthermore, functional gene structure of saliva microbiota could potentially distinguish caries-active patients from healthy hosts. Microbial functions such as Diaminopimelate epimerase, Prephenate dehydrogenase, Pyruvate-formate lyase and N-acetylmuramoyl-L-alanine amidase were significantly linked to caries. Therefore, saliva microbiota carried disease-associated functional signatures, which could be potentially exploited for caries diagnosis. |
| 文章类型 | Article |
| WOS标题词 | Science & Technology |
| DOI | 10.1371/journal.pone.0076458 |
| 关键词[WOS] | SEA OIL PLUME ; STREPTOCOCCUS-MUTANS ; CHILDHOOD CARIES ; DENTAL-CARIES ; WHOLE-SALIVA ; ASSOCIATION ; EXPERIENCE ; COMMUNITY ; CHILDREN ; DIVERSITY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| WOS记录号 | WOS:000331262600001 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qibebt.ac.cn/handle/337004/6259 |
| 专题 | 单细胞中心组群 |
| 作者单位 | 1.Qingdao Municipal Hosp, Oral Res Ctr, Qingdao, Shandong, Peoples R China 2.Chinese Acad Sci, CAS Key Lab Biofuels, Shandong Key Lab Energy Genet, Qingdao, Shandong, Peoples R China 3.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, BioEnergy Genome Ctr, Qingdao, Shandong, Peoples R China 4.Univ Oklahoma, Inst Environm Genom, Norman, OK 73019 USA 5.Univ Calif Riverside, Dept Stat, Riverside, CA 92521 USA |
| 推荐引用方式 GB/T 7714 | Yang, Fang,Ning, Kang,Chang, Xingzhi,et al. Saliva Microbiota Carry Caries-Specific Functional Gene Signatures[J]. PLOS ONE,2014,9(2). |
| APA | Yang, Fang.,Ning, Kang.,Chang, Xingzhi.,Yuan, Xiao.,Tu, Qichao.,...&Xu, Jian.(2014).Saliva Microbiota Carry Caries-Specific Functional Gene Signatures.PLOS ONE,9(2). |
| MLA | Yang, Fang,et al."Saliva Microbiota Carry Caries-Specific Functional Gene Signatures".PLOS ONE 9.2(2014). |
| 条目包含的文件 | 条目无相关文件。 | |||||
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