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High Impedance Droplet-Solid Interface Lipid Bilayer Membranes
Wang, Xuejing1; Ma, Shenghua1; Su, Yingchun1; Zhang, Ying1; Bi, Hongmei1; Zhang, Lixue2; Han, Xiaojun1
2015-02-17
发表期刊ANALYTICAL CHEMISTRY
卷号87期号:4页码:2094-2099
摘要

A droplet-solid interface lipid bilayer membrane (DSLM) with high impedance was developed through controlling the contact area between an aqueous droplet and electrode. The electrode size can be easily controlled from millimeter to micrometer level. The droplet-solid interface lipid bilayer membranes were characterized by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and fluorescence microscopy. The fluorescence recovery after photobleaching (FRAP) was applied to determine the diffusion coefficient of egg PC DSLM to be 2.58 mu m(2) s(-1). The DSLM resistance can reach up to 26.3 G Omega, which was then used to study the ion channel behavior of melittin. The resistivity of the bilayer membrane decreased linearly with the increase of melittin concentration in the membrane. The high impedance and fluidity of DSLM makes it an ideal model cell membrane system for ion channel study and high-throughput drug screening.

文章类型Article
WOS标题词Science & Technology ; Physical Sciences
DOI10.1021/ac502953v
关键词[WOS]CHANNEL ACTIVITY ; PHOSPHOLIPID-BILAYERS ; ELECTRICAL-PROPERTIES ; POROUS ALUMINA ; MELITTIN ; NANOPORE ; SPECTROSCOPY ; PORES ; THIOLIPIDS ; ELECTRODES
收录类别SCI
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Analytical
WOS记录号WOS:000349806200014
引用统计
文献类型期刊论文
条目标识符http://ir.qibebt.ac.cn/handle/337004/6094
专题仿生与固态能源系统研究组
作者单位1.Harbin Inst Technol, State Key Lab Urban Water Resource & Environm, Sch Chem Engn & Technol, Harbin 150001, Peoples R China
2.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao Key Lab Solar Energy Utilizat & Energy St, Qingdao 266101, Peoples R China
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GB/T 7714
Wang, Xuejing,Ma, Shenghua,Su, Yingchun,et al. High Impedance Droplet-Solid Interface Lipid Bilayer Membranes[J]. ANALYTICAL CHEMISTRY,2015,87(4):2094-2099.
APA Wang, Xuejing.,Ma, Shenghua.,Su, Yingchun.,Zhang, Ying.,Bi, Hongmei.,...&Han, Xiaojun.(2015).High Impedance Droplet-Solid Interface Lipid Bilayer Membranes.ANALYTICAL CHEMISTRY,87(4),2094-2099.
MLA Wang, Xuejing,et al."High Impedance Droplet-Solid Interface Lipid Bilayer Membranes".ANALYTICAL CHEMISTRY 87.4(2015):2094-2099.
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