Phylogenetic and Evolutionary Analyses of the Animal Hairy and Enhancer of Split Basic Helix-loop-helix Transcription Factors

doi:10.3923/ajava.2012.390.402

QIBEBT-IR > 仿生与固态能源系统研究组

	Phylogenetic and Evolutionary Analyses of the Animal Hairy and Enhancer of Split Basic Helix-loop-helix Transcription Factors
	Liu, Wu-yi 1,2; Zhang, Ke-jun 3
	2012-05-01
发表期刊	ASIAN JOURNAL OF ANIMAL AND VETERINARY ADVANCES
卷号	7 期号:5 页码:390-402
摘要	The basic helix-loop-helix (bHLH) transcription factors are the products of main regulatory genes in metazoans. Regulatory genes are usually believed to play a large role in morphological and genetic diversifications and are often characterized by elevatedrates of evolution. In previous studies, it was showed there was much genetic diversification among the members of Hairy and Enhancer of split (Hairy/E(spl) or H/E(spl)) bHLH family. This promoted us to do further research on the mechanism of genetic diversification within the H/E(spl) bHLH family. With all the data available, we carried out an evolutionary analysis among sequence sites of the enlarged H/E(spl) bHLH family and reported that all the Hes gene lineages were under purifying selection, but the Hes2, Hes3, Hes5 lineages evolved faster than the other ones with relatively higher omega values. We found nine sites of Hes5 genes under significantly positive selection and concluded that the diversity of H/E(spl) genes has been established through relaxed selective constraint.
文章类型	Article
关键词	Transcription Factor Hairy And Enhancer Of Split Bhlh Selective Pressure
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
DOI	10.3923/ajava.2012.390.402
关键词[WOS]	AMINO-ACID SITES ; CODON-SUBSTITUTION MODELS ; DROSOPHILA-MELANOGASTER ; FACTOR FAMILY ; GENOME-WIDE ; EARLY NEUROGENESIS ; MAXIMUM-LIKELIHOOD ; GENETIC MECHANISMS ; POSITIVE SELECTION ; PROTEINS
收录类别	SCI
语种	英语
WOS研究方向	Veterinary Sciences
WOS类目	Veterinary Sciences
WOS记录号	WOS:000303101700003
引用统计
文献类型	期刊论文
条目标识符	http://ir.qibebt.ac.cn/handle/337004/6069
专题	仿生与固态能源系统研究组
作者单位	1.Fuyang Normal Coll, Dept Sci Res, Fuyang City 236041, Peoples R China 2.Fuyang Normal Coll, Dept Biol Sci, Fuyang City 236041, Peoples R China 3.Chinese Acad Sci, Qingdao Inst Biomass Energy & Bioproc Technol, Qingdao 266101, Peoples R China
推荐引用方式 GB/T 7714	Liu, Wu-yi,Zhang, Ke-jun. Phylogenetic and Evolutionary Analyses of the Animal Hairy and Enhancer of Split Basic Helix-loop-helix Transcription Factors[J]. ASIAN JOURNAL OF ANIMAL AND VETERINARY ADVANCES,2012,7(5):390-402.
APA	Liu, Wu-yi,&Zhang, Ke-jun.(2012).Phylogenetic and Evolutionary Analyses of the Animal Hairy and Enhancer of Split Basic Helix-loop-helix Transcription Factors.ASIAN JOURNAL OF ANIMAL AND VETERINARY ADVANCES,7(5),390-402.
MLA	Liu, Wu-yi,et al."Phylogenetic and Evolutionary Analyses of the Animal Hairy and Enhancer of Split Basic Helix-loop-helix Transcription Factors".ASIAN JOURNAL OF ANIMAL AND VETERINARY ADVANCES 7.5(2012):390-402.