Production of Block Copolymer Poly(3-hydroxybutyrate)-block-poly(3-hydroxypropionate) with Adjustable Structure from an Inexpensive Carbon Source

doi:10.1021/mz400446g

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	Production of Block Copolymer Poly(3-hydroxybutyrate)-block-poly(3-hydroxypropionate) with Adjustable Structure from an Inexpensive Carbon Source
	Wang, Qi 1,2; Yang, Peng 1,3; Xian, Mo1 ; Liu, Hui1 ; Cao, Yujin1 ; Yang, Ying1 ; Zhao, Guang 1
	2013-11-01
发表期刊	ACS MACRO LETTERS
卷号	2 期号:11 页码:996-1000
摘要	The block copolymers poly(3-hydroxybutyrate)-block-poly(3-hydroxypropionate) (P3HB-b-P3HP) with a wide range of 3HP fractions from 7.4 mol % to 75 mol % were biosynthesized from inexpensive carbon sources for the first time, differing from previously reported approaches based on sequential addition of precursors. The engineered Escherichia coli strain carried two parallel synthetic pathways modulated by independent regulatory systems to produce the 3HB and 3HP monomers, respectively. Manipulating the expression levels of 3HB and 3HP pathways resulted in biosynthesis of block copolymers P3HB-b-P3HP with varied compositions. Nuclear magnetic resonance and differential scanning calorimetric studies demonstrated novel microstructure and thermal properties not available in related random copolymers and a blend of P3HB and P3HP homopolymers.
文章类型	Article
WOS标题词	Science & Technology ; Physical Sciences
DOI	10.1021/mz400446g
关键词[WOS]	RECOMBINANT ESCHERICHIA-COLI ; PSEUDOMONAS-PUTIDA KT2442 ; DIBLOCK COPOLYMER ; BIOSYNTHESIS ; POLYHYDROXYALKANOATES ; POLYESTERS ; GLYCEROL
收录类别	SCI
语种	英语
WOS研究方向	Polymer Science
WOS类目	Polymer Science
WOS记录号	WOS:000326955500010
引用统计
文献类型	期刊论文
条目标识符	http://ir.qibebt.ac.cn/handle/337004/6033
专题	生物基材料组群
作者单位	1.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, CAS Key Lab Biobased Mat, Qingdao 266101, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Dalian Polytech Univ, Sch Biol Engn, Dalian 116034, Peoples R China
推荐引用方式 GB/T 7714	Wang, Qi,Yang, Peng,Xian, Mo,et al. Production of Block Copolymer Poly(3-hydroxybutyrate)-block-poly(3-hydroxypropionate) with Adjustable Structure from an Inexpensive Carbon Source[J]. ACS MACRO LETTERS,2013,2(11):996-1000.
APA	Wang, Qi.,Yang, Peng.,Xian, Mo.,Liu, Hui.,Cao, Yujin.,...&Zhao, Guang.(2013).Production of Block Copolymer Poly(3-hydroxybutyrate)-block-poly(3-hydroxypropionate) with Adjustable Structure from an Inexpensive Carbon Source.ACS MACRO LETTERS,2(11),996-1000.
MLA	Wang, Qi,et al."Production of Block Copolymer Poly(3-hydroxybutyrate)-block-poly(3-hydroxypropionate) with Adjustable Structure from an Inexpensive Carbon Source".ACS MACRO LETTERS 2.11(2013):996-1000.