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Problems with the microbial production of butanol
Zheng, Yan-Ning1; Li, Liang-Zhi1; Xian, Mo1; Ma, Yu-Jiu1; Yang, Jian-Ming1; Xu, Xin1; He, Dong-Zhi2
2009-09-01
发表期刊JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
ISSNISSN : 1476-5535
卷号36期号:9页码:1127-1138
摘要With the incessant fluctuations in oil prices and increasing stress from environmental pollution, renewed attention is being paid to the microbial production of biofuels from renewable sources. As a gasoline substitute, butanol has advantages over traditional fuel ethanol in terms of energy density and hygroscopicity. A variety of cheap substrates have been successfully applied in the production of biobutanol, highlighting the commercial potential of biobutanol development. In this review, in order to better understand the process of acetone-butanol-ethanol production, traditional clostridia fermentation is discussed. Sporulation is probably induced by solvent formation, and the molecular mechanism leading to the initiation of sporulation and solventogenesis is also investigated. Different strategies are employed in the metabolic engineering of clostridia that aim to enhancing solvent production, improve selectivity for butanol production, and increase the tolerance of clostridia to solvents. However, it will be hard to make breakthroughs in the metabolic engineering of clostridia for butanol production without gaining a deeper understanding of the genetic background of clostridia and developing more efficient genetic tools for clostridia. Therefore, increasing attention has been paid to the metabolic engineering of E. coli for butanol production. The importation and expression of a non-clostridial butanol-producing pathway in E. coli is probably the most promising strategy for butanol biosynthesis. Due to the lower butanol titers in the fermentation broth, simultaneous fermentation and product removal techniques have been developed to reduce the cost of butanol recovery. Gas stripping is the best technique for butanol recovery found so far.; With the incessant fluctuations in oil prices and increasing stress from environmental pollution, renewed attention is being paid to the microbial production of biofuels from renewable sources. As a gasoline substitute, butanol has advantages over traditional fuel ethanol in terms of energy density and hygroscopicity. A variety of cheap substrates have been successfully applied in the production of biobutanol, highlighting the commercial potential of biobutanol development. In this review, in order to better understand the process of acetone-butanol-ethanol production, traditional clostridia fermentation is discussed. Sporulation is probably induced by solvent formation, and the molecular mechanism leading to the initiation of sporulation and solventogenesis is also investigated. Different strategies are employed in the metabolic engineering of clostridia that aim to enhancing solvent production, improve selectivity for butanol production, and increase the tolerance of clostridia to solvents. However, it will be hard to make breakthroughs in the metabolic engineering of clostridia for butanol production without gaining a deeper understanding of the genetic background of clostridia and developing more efficient genetic tools for clostridia. Therefore, increasing attention has been paid to the metabolic engineering of E. coli for butanol production. The importation and expression of a non-clostridial butanol-producing pathway in E. coli is probably the most promising strategy for butanol biosynthesis. Due to the lower butanol titers in the fermentation broth, simultaneous fermentation and product removal techniques have been developed to reduce the cost of butanol recovery. Gas stripping is the best technique for butanol recovery found so far.
文章类型Review
关键词Butanol Fermentation Metabolic Engineering Clostridia E. Coli Recovery Techniques
学科领域生物基化学品
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1007/s10295-009-0609-9
关键词[WOS]CLOSTRIDIUM-BEIJERINCKII BA101 ; ACETOBUTYLICUM ATCC 824 ; INCREASED SOLVENT PRODUCTION ; FACTOR HOMOLOGOUS GENES ; FERMENTATION PROCESS ; ACETONE FORMATION ; DOWN-REGULATION ; TRANSCRIPTIONAL REPRESSOR ; SYNTHETIC GENES ; REPORTER GENE
收录类别SCI
语种英语
WOS研究方向Biotechnology & Applied Microbiology
WOS类目Biotechnology & Applied Microbiology
WOS记录号WOS:000269193600001
引用统计
被引频次:155[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qibebt.ac.cn/handle/337004/460
专题材料生物技术研究中心
作者单位1.Chinese Acad Sci, Key Lab Biofuels, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao 266071, Peoples R China
2.Dalian Polytech Univ, Coll Profess Technol, Dalian 116221, Peoples R China
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Zheng, Yan-Ning,Li, Liang-Zhi,Xian, Mo,et al. Problems with the microbial production of butanol[J]. JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY,2009,36(9):1127-1138.
APA Zheng, Yan-Ning.,Li, Liang-Zhi.,Xian, Mo.,Ma, Yu-Jiu.,Yang, Jian-Ming.,...&He, Dong-Zhi.(2009).Problems with the microbial production of butanol.JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY,36(9),1127-1138.
MLA Zheng, Yan-Ning,et al."Problems with the microbial production of butanol".JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY 36.9(2009):1127-1138.
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