QIBEBT-IR  > 生物基材料组群
Optimization of the medium for streptolydigin production by Streptomyces lydicus AS 4.2501 with precursor feeding using response surface methodology
Li, Liang-zhi1,2; Zheng, Hui1; Xian, Mo2
2010-05-01
发表期刊JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
ISSNISSN: 1876-1070
卷号41期号:3页码:252-258
摘要Plackett-Burman multifactorial design and the consequent response surface methodology (RSM) were used to improve the streptolydigin yield in a newly isolated strain Streptomyces lydicus AS 4.2501 with a dramatic streptolydigin increase of 18.6%. Also propionate's role as a precursor for the streptolydigin biosynthesis was for the first time practically validated. The results from the Plackett-Burman design showed that starch, peptone and K(2)HPO(4) were influential factors to the biosynthesis of streptolydigin. Consequent analysis with RSM not only detected the interactions among these important factors, but also established two models referring to the streptolydigin titer and biomass, respectively. Additionally, the relationship between the production of streptolydigin and the growth of mycelia was first discussed using statistical methods, which is of great help to the overproduction of the related secondary metabolites.; Plackett-Burman multifactorial design and the consequent response surface methodology (RSM) were used to improve the streptolydigin yield in a newly isolated strain Streptomyces lydicus AS 4.2501 with a dramatic streptolydigin increase of 18.6%. Also propionate's role as a precursor for the streptolydigin biosynthesis was for the first time practically validated. The results from the Plackett-Burman design showed that starch, peptone and K(2)HPO(4) were influential factors to the biosynthesis of streptolydigin. Consequent analysis with RSM not only detected the interactions among these important factors, but also established two models referring to the streptolydigin titer and biomass, respectively. Additionally, the relationship between the production of streptolydigin and the growth of mycelia was first discussed using statistical methods, which is of great help to the overproduction of the related secondary metabolites. (C) 2010 Published by Elsevier B.V. on behalf of Taiwan Institute of Chemical Engineers.
文章类型Article
关键词Response Surface Methodology Fermentation Streptolydigin Optimization Streptomyces Lydicus
学科领域生物基化学品
WOS标题词Science & Technology ; Technology
DOI10.1016/j.jtice.2009.11.001
关键词[WOS]RNA-POLYMERASE ; LACTIC-ACID ; BIOSYNTHESIS ; FERMENTATION ; DESIGN ; INHIBITION ; PROPIONATE ; LIPASE ; CARBON ; PH
收录类别SCI
语种英语
WOS研究方向Engineering
WOS类目Engineering, Chemical
WOS记录号WOS:000278239900002
引用统计
文献类型期刊论文
条目标识符http://ir.qibebt.ac.cn/handle/337004/458
专题生物基材料组群
作者单位1.Tianjin Univ, Sch Chem Engn & Technol, Dept Pharmaceut Engn, Tianjin 300072, Peoples R China
2.Chinese Acad Sci, Qingdao Inst BioEnergy & Bioproc Technol, Qingdao 266071, Peoples R China
推荐引用方式
GB/T 7714
Li, Liang-zhi,Zheng, Hui,Xian, Mo. Optimization of the medium for streptolydigin production by Streptomyces lydicus AS 4.2501 with precursor feeding using response surface methodology[J]. JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS,2010,41(3):252-258.
APA Li, Liang-zhi,Zheng, Hui,&Xian, Mo.(2010).Optimization of the medium for streptolydigin production by Streptomyces lydicus AS 4.2501 with precursor feeding using response surface methodology.JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS,41(3),252-258.
MLA Li, Liang-zhi,et al."Optimization of the medium for streptolydigin production by Streptomyces lydicus AS 4.2501 with precursor feeding using response surface methodology".JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS 41.3(2010):252-258.
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Optimization of the (627KB) 开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Li, Liang-zhi]的文章
[Zheng, Hui]的文章
[Xian, Mo]的文章
百度学术
百度学术中相似的文章
[Li, Liang-zhi]的文章
[Zheng, Hui]的文章
[Xian, Mo]的文章
必应学术
必应学术中相似的文章
[Li, Liang-zhi]的文章
[Zheng, Hui]的文章
[Xian, Mo]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Optimization of the medium for streptolydigin production by Streptomyces lydicus AS 4.2501 with precursor feeding using response surface methodology.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。