QIBEBT-IR
Comparative Analysis of the Microbial Profiles in Supragingival Plaque Samples Obtained From Twins With Discordant Caries Phenotypes and Their Mothers
Zheng, Yuqiao1; Zhang, Meng1; Li, Jin1; Li, Yuhong1; Teng, Fei2; Jiang, Han1; Du, Minquan1
2018-10-16
Source PublicationFRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
ISSN2235-2988
Volume8Pages:13
AbstractEarly childhood caries (ECC), the most frequent disease of oral cavity in preschool children, is the consequence of microbial, genetic, biochemical, socioeconomic, physical, environmental and health-influencing behavioral factors. To investigate the role of the oral microbiome and the impact of host and environmental factors in the occurrence and development of ECC, we studied the supragingival plaques of 14 twin pairs and a set of triplets with discordant caries phenotypes and 15 mothers, applying the Human Oral Microbe Identification using Next Generation Sequencing technique (HOMINGS). A total of 2,293,650 reads revealed 11 phyla, 116 genera, and 139 species of micromiome. Comparative analysis between the caries and caries-free group at species level revealed that the relative abundance of Streptococcus mutans, Lactobacillus fermentum, Actinomyces islaelii, Neisseria sica, and Veilonella dispar was much higher in caries group (P < 0.0001). Furthermore, monozygotic twins exhibited a higher degree of similarity than dizygotic twins. Finally, we analyzed the relationship between environmental factors and the oral microbiome, and our results indicat that the frequency of taking sweet food is associated with ECC. We conclude the following. First, the occurrence of Streptococcus mutans, Lactobacillus fermentum, Neisseria sica, and Veilonella dispar is strongly associated with the occurrence of ECC. Second, host genetic factors influence the oral microbiome composition, while environmental and behavioral factors like the frequency of taking sweet foods have an impact on the distribution of caries-related bacteria.
Keywordearly childhood caries supragingival plaque twins oral microbiome mother
DOI10.3389/fcimb.2018.00361
WOS KeywordEARLY-CHILDHOOD CARIES ; DENTAL-CARIES ; DIZYGOTIC TWINS ; STREPTOCOCCUS-MUTANS ; PRESCHOOL-CHILDREN ; ENVIRONMENTAL-FACTORS ; BACTERIAL DIVERSITY ; MONOZYGOTIC TWINS ; PERMANENT TEETH ; ACQUISITION
Language英语
Funding ProjectNational Natural Science Foundation of China[81170954]
WOS Research AreaImmunology ; Microbiology
Funding OrganizationNational Natural Science Foundation of China
WOS SubjectImmunology ; Microbiology
WOS IDWOS:000447377600002
PublisherFRONTIERS MEDIA SA
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qibebt.ac.cn/handle/337004/11752
Collection中国科学院青岛生物能源与过程研究所
Corresponding AuthorLi, Yuhong; Du, Minquan
Affiliation1.Wuhan Univ, Hubei Most KLOS&KLOBM, Sch & Hosp Stomatol, Wuhan, Hubei, Peoples R China
2.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao, Shandong, Peoples R China
Recommended Citation
GB/T 7714
Zheng, Yuqiao,Zhang, Meng,Li, Jin,et al. Comparative Analysis of the Microbial Profiles in Supragingival Plaque Samples Obtained From Twins With Discordant Caries Phenotypes and Their Mothers[J]. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY,2018,8:13.
APA Zheng, Yuqiao.,Zhang, Meng.,Li, Jin.,Li, Yuhong.,Teng, Fei.,...&Du, Minquan.(2018).Comparative Analysis of the Microbial Profiles in Supragingival Plaque Samples Obtained From Twins With Discordant Caries Phenotypes and Their Mothers.FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY,8,13.
MLA Zheng, Yuqiao,et al."Comparative Analysis of the Microbial Profiles in Supragingival Plaque Samples Obtained From Twins With Discordant Caries Phenotypes and Their Mothers".FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY 8(2018):13.
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