KMS Qingdao Institute of Biomass Energy and Bioprocess Technology ,CAS
Comparative Analysis of the Microbial Profiles in Supragingival Plaque Samples Obtained From Twins With Discordant Caries Phenotypes and Their Mothers | |
Zheng, Yuqiao1; Zhang, Meng1; Li, Jin1; Li, Yuhong1; Teng, Fei2; Jiang, Han1; Du, Minquan1 | |
2018-10-16 | |
发表期刊 | FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY |
ISSN | 2235-2988 |
卷号 | 8页码:13 |
摘要 | Early childhood caries (ECC), the most frequent disease of oral cavity in preschool children, is the consequence of microbial, genetic, biochemical, socioeconomic, physical, environmental and health-influencing behavioral factors. To investigate the role of the oral microbiome and the impact of host and environmental factors in the occurrence and development of ECC, we studied the supragingival plaques of 14 twin pairs and a set of triplets with discordant caries phenotypes and 15 mothers, applying the Human Oral Microbe Identification using Next Generation Sequencing technique (HOMINGS). A total of 2,293,650 reads revealed 11 phyla, 116 genera, and 139 species of micromiome. Comparative analysis between the caries and caries-free group at species level revealed that the relative abundance of Streptococcus mutans, Lactobacillus fermentum, Actinomyces islaelii, Neisseria sica, and Veilonella dispar was much higher in caries group (P < 0.0001). Furthermore, monozygotic twins exhibited a higher degree of similarity than dizygotic twins. Finally, we analyzed the relationship between environmental factors and the oral microbiome, and our results indicat that the frequency of taking sweet food is associated with ECC. We conclude the following. First, the occurrence of Streptococcus mutans, Lactobacillus fermentum, Neisseria sica, and Veilonella dispar is strongly associated with the occurrence of ECC. Second, host genetic factors influence the oral microbiome composition, while environmental and behavioral factors like the frequency of taking sweet foods have an impact on the distribution of caries-related bacteria. |
关键词 | early childhood caries supragingival plaque twins oral microbiome mother |
DOI | 10.3389/fcimb.2018.00361 |
关键词[WOS] | EARLY-CHILDHOOD CARIES ; DENTAL-CARIES ; DIZYGOTIC TWINS ; STREPTOCOCCUS-MUTANS ; PRESCHOOL-CHILDREN ; ENVIRONMENTAL-FACTORS ; BACTERIAL DIVERSITY ; MONOZYGOTIC TWINS ; PERMANENT TEETH ; ACQUISITION |
语种 | 英语 |
资助项目 | National Natural Science Foundation of China[81170954] |
WOS研究方向 | Immunology ; Microbiology |
项目资助者 | National Natural Science Foundation of China |
WOS类目 | Immunology ; Microbiology |
WOS记录号 | WOS:000447377600002 |
出版者 | FRONTIERS MEDIA SA |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.qibebt.ac.cn/handle/337004/11752 |
专题 | 中国科学院青岛生物能源与过程研究所 |
通讯作者 | Li, Yuhong; Du, Minquan |
作者单位 | 1.Wuhan Univ, Hubei Most KLOS&KLOBM, Sch & Hosp Stomatol, Wuhan, Hubei, Peoples R China 2.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao, Shandong, Peoples R China |
推荐引用方式 GB/T 7714 | Zheng, Yuqiao,Zhang, Meng,Li, Jin,et al. Comparative Analysis of the Microbial Profiles in Supragingival Plaque Samples Obtained From Twins With Discordant Caries Phenotypes and Their Mothers[J]. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY,2018,8:13. |
APA | Zheng, Yuqiao.,Zhang, Meng.,Li, Jin.,Li, Yuhong.,Teng, Fei.,...&Du, Minquan.(2018).Comparative Analysis of the Microbial Profiles in Supragingival Plaque Samples Obtained From Twins With Discordant Caries Phenotypes and Their Mothers.FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY,8,13. |
MLA | Zheng, Yuqiao,et al."Comparative Analysis of the Microbial Profiles in Supragingival Plaque Samples Obtained From Twins With Discordant Caries Phenotypes and Their Mothers".FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY 8(2018):13. |
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