QIBEBT-IR
Responses of Antioxidant Defense and Immune Gene Expression in Early Life Stages of Large Yellow Croaker (Pseudosciaena crocea) Under Methyl Mercury Exposure
Wu, Fangzhu1; Huang, Wei1; Liu, Qiang1; Xu, Xiaoqun1; Zeng, Jiangning1,2; Cao, Liang3; Hu, Ji1; Xu, Xudan1; Gao, Yuexin1; Jia, Shenghua1,4
2018-10-10
发表期刊FRONTIERS IN PHYSIOLOGY
ISSN1664-042X
卷号9页码:10
摘要Early life stages of marine organisms are the most sensitive stages to environment stressors including pollutants. In order to understand the toxicological effects induced by MeHg exposure on juveniles of large yellow croaker (Pseudosciaena crocea), a toxicity test was performed wherein fish were exposed to sub-lethal concentrations of MeHg under laboratory conditions (18 +/- 1 degrees C; 26 +/- 1 in salinity). After 30 days of 0-4.0 mu g L-1 MeHg exposure, SOD activity was significantly decreased in the 0.25, 1.0, and 4.0 mu g L-1 treatments; while CAT activity was significantly increased in the 4.0 mu g L-1 treatments; GSH level, GPx activity were significantly elevated in the 4.0 mu g L-1 treatments, respectively. Meanwhile, malondialdehyde content was also significantly increased in the 1.0 and 4.0 mu g L-1 treatments with respect to the control. Acetylcholinesterase activity was significantly decreased by 18.3, 25.2, and 21.7% in the 0.25, 1.0, and 4.0 mu g L-1 treatments, respectively. The expression of TCTP, GST3, Hsp70, Hsp27 mRNA were all up-regulated in juveniles with a dose-dependent manner exposed to MeHg. These results suggest that large yellow croaker juveniles have the potential to regulate the levels of antioxidant enzymes and initiate immune response in order to protect fish to some extent from oxidative stress induced by MeHg.
关键词large yellow croaker juvenile MeHg exposure antioxidant defense system mRNA expression
DOI10.3389/fphys.2018.01436
关键词[WOS]CONTROLLED TUMOR PROTEIN ; MAPK SIGNALING PATHWAYS ; ZEBRAFISH DANIO-RERIO ; OXIDATIVE STRESS ; METHYLMERCURY MEHG ; CARASSIUS-AURATUS ; CELL-DEATH ; DIETARY METHYLMERCURY ; INDUCED NEUROTOXICITY ; LIPID-PEROXIDATION
语种英语
资助项目National Marine Public Welfare Research Project of China[201405007] ; National Natural Science Foundation of China[41306112] ; National Natural Science Foundation of China[41406167] ; National Natural Science Foundation of China[21307019] ; China-APEC Cooperation Fund[2029901] ; Science and Technology Support Program of China[2015BAD08B01] ; Basic Scientific Research of SIO, China[JG1717] ; Basic Scientific Research of SIO, China[JG1526]
WOS研究方向Physiology
项目资助者National Marine Public Welfare Research Project of China ; National Natural Science Foundation of China ; China-APEC Cooperation Fund ; Science and Technology Support Program of China ; Basic Scientific Research of SIO, China
WOS类目Physiology
WOS记录号WOS:000446897000001
出版者FRONTIERS MEDIA SA
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qibebt.ac.cn/handle/337004/11746
专题中国科学院青岛生物能源与过程研究所
通讯作者Huang, Wei
作者单位1.State Ocean Adm, Inst Oceanog 2, Key Lab Marine Ecosyst & Biogeochem, Hangzhou, Zhejiang, Peoples R China
2.Zhejiang Univ, Ocean Coll, Hangzhou, Zhejiang, Peoples R China
3.Chinese Acad Sci, Inst Oceanol, Qingdao, Peoples R China
4.Zhejiang Surveying Inst Estuary & Coast, Hangzhou, Zhejiang, Peoples R China
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Wu, Fangzhu,Huang, Wei,Liu, Qiang,et al. Responses of Antioxidant Defense and Immune Gene Expression in Early Life Stages of Large Yellow Croaker (Pseudosciaena crocea) Under Methyl Mercury Exposure[J]. FRONTIERS IN PHYSIOLOGY,2018,9:10.
APA Wu, Fangzhu.,Huang, Wei.,Liu, Qiang.,Xu, Xiaoqun.,Zeng, Jiangning.,...&Jia, Shenghua.(2018).Responses of Antioxidant Defense and Immune Gene Expression in Early Life Stages of Large Yellow Croaker (Pseudosciaena crocea) Under Methyl Mercury Exposure.FRONTIERS IN PHYSIOLOGY,9,10.
MLA Wu, Fangzhu,et al."Responses of Antioxidant Defense and Immune Gene Expression in Early Life Stages of Large Yellow Croaker (Pseudosciaena crocea) Under Methyl Mercury Exposure".FRONTIERS IN PHYSIOLOGY 9(2018):10.
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