QIBEBT-IR
Aspergixanthones I-K, New Anti-Vibrio Prenylxanthones from the Marine-Derived Fungus Aspergillus sp ZA-01
Zhu, Ao1; Zhang, Xing-Wang2; Zhang, Miao1; Li, Wan1; Ma, Zheng-Yue1; Zhu, Hua-Jie1; Cao, Fei1
2018-09-01
发表期刊MARINE DRUGS
ISSN1660-3397
卷号16期号:9页码:8
摘要Marine-derived fungi are a rich source of structurally diverse metabolites. Fungi produce an array of compounds when grown under different cultivation conditions. In the present work, different media were used to cultivate the fungus Aspergillus sp. ZA-01, which was previously studied for the production of bioactive compounds, and three new prenylxanthone derivatives, aspergixanthones I-K (1-3), and four known analogues (4-7) were obtained. The absolute configuration of 1 was assigned by ECD experiment and the Mo-2(AcO)(4) ICD spectrum of its methanolysis derivative (1a). All the compounds (1-7) were evaluated for their anti-Vibrio activities. Aspergixanthone I (1) showed the strongest anti-Vibrio activity against Vibrio parahemolyticus (MIC = 1.56 M), Vibrio anguillarum (MIC = 1.56 M), and Vibrio alginolyticus (MIC = 3.12 M).
关键词marine-derived fungus Aspergillus sp prenylxanthone anti-Vibrio activity
DOI10.3390/md16090312
关键词[WOS]EMERICELLA SP ; DERIVATIVES
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal
WOS记录号WOS:000445636600023
出版者MDPI
引用统计
文献类型期刊论文
条目标识符http://ir.qibebt.ac.cn/handle/337004/11633
专题中国科学院青岛生物能源与过程研究所
通讯作者Zhu, Hua-Jie; Cao, Fei
作者单位1.Hebei Univ, Coll Pharmaceut Sci, Educ Minist China, Key Lab Pharmaceut Qual Control Hebei Prov,Key La, Baoding 071002, Peoples R China
2.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, CAS Key Lab Biofuels, Shandong Prov Key Lab Synthet Biol, Qingdao 266101, Peoples R China
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Zhu, Ao,Zhang, Xing-Wang,Zhang, Miao,et al. Aspergixanthones I-K, New Anti-Vibrio Prenylxanthones from the Marine-Derived Fungus Aspergillus sp ZA-01[J]. MARINE DRUGS,2018,16(9):8.
APA Zhu, Ao.,Zhang, Xing-Wang.,Zhang, Miao.,Li, Wan.,Ma, Zheng-Yue.,...&Cao, Fei.(2018).Aspergixanthones I-K, New Anti-Vibrio Prenylxanthones from the Marine-Derived Fungus Aspergillus sp ZA-01.MARINE DRUGS,16(9),8.
MLA Zhu, Ao,et al."Aspergixanthones I-K, New Anti-Vibrio Prenylxanthones from the Marine-Derived Fungus Aspergillus sp ZA-01".MARINE DRUGS 16.9(2018):8.
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