KMS Qingdao Institute of Biomass Energy and Bioprocess Technology ,CAS
| Carboxymethyl konjac glucomannan - crosslinked chitosan sponges for wound dressing | |
Xie, Yu1,3,4 ; Yi, Zeng-xing1,3,4; Wang, Jian-xun2,3,4; Hou, Tong-gang2,3,4; Jiang, Qiong1,3,4
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| 2018-06-01 | |
| Source Publication | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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| ISSN | 0141-8130 |
| Volume | 112Pages:1225-1233 |
| Abstract | In this paper, carboxymethyl konjac glucomannan (CMKGM) was obtained by carboxyl modification of konjac glucomannan. Then CMKGM and chitosan (CS) were crosslinked and freeze-dried to prepare CMKGM/CS composite sponges with different proportions. The structure and micromorphology of CMKGM/CS sponges were investigated by FTIR spectroscopy and SEM. The SEM results showed that the pore structure of the composite sponge gradually increased with the increase of CMKGM content To assess the applicability of CMKGM/CS composite sponges as wound dressing, the swelling behavior, water vapor transmission rate (WVYR), biocompatibility (cytotoxicity and hemolysis) were analyzed. The results indicated that CMKGM/CS composite sponges possessed high swelling ratio, proper WVTR and good biocompatibility, which might accelerate tissue regeneration. Meanwhile, in vivo experiments demonstrated that CMKGM/CS composite sponges could effectively heal full-layer wound of skin defects of male ICR mice. (C) 2018 Elsevier B.V. All rights reserved. |
| Subtype | Article |
| Keyword | Cmkgm Sponge Wound Dressing |
| WOS Headings | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences |
| DOI | 10.1016/j.ijbiomac.2018.02.075 |
| WOS Keyword | HYDROGEL ; DERIVATIVES ; BIOMATERIALS ; CELLULOSE ; CHITIN ; FILMS |
| Indexed By | SCI |
| Language | 英语 |
| WOS Research Area | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| Funding Organization | Open foundation of Key Laboratory of biological base materials, Chinese Academy of Sciences ; Yichun science and technology innovation platform and innovation team plan project(20160609) ; project of local development research center of Yichun University(2016025) |
| WOS Subject | Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science |
| WOS ID | WOS:000430522400144 |
| Publisher | ELSEVIER SCIENCE BV |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.qibebt.ac.cn/handle/337004/11502 |
| Collection | 中国科学院青岛生物能源与过程研究所 |
| Corresponding Author | Jiang, Qiong |
| Affiliation | 1.Yichun Univ, Coll Chem & Bioengn, Yichun 336000, Peoples R China 2.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, CAS Key Lab Biobased Mat, Qingdao 266101, Peoples R China 3.Chinese Acad Sci, Joint Res Ctr, Qingdao Inst Bioenergy & Bioproc Technol, Yichun 336000, Peoples R China 4.Yichun Univ, Yichun 336000, Peoples R China |
| Recommended Citation GB/T 7714 | Xie, Yu,Yi, Zeng-xing,Wang, Jian-xun,et al. Carboxymethyl konjac glucomannan - crosslinked chitosan sponges for wound dressing[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2018,112:1225-1233. |
| APA | Xie, Yu,Yi, Zeng-xing,Wang, Jian-xun,Hou, Tong-gang,&Jiang, Qiong.(2018).Carboxymethyl konjac glucomannan - crosslinked chitosan sponges for wound dressing.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,112,1225-1233. |
| MLA | Xie, Yu,et al."Carboxymethyl konjac glucomannan - crosslinked chitosan sponges for wound dressing".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 112(2018):1225-1233. |
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