KMS Qingdao Institute of Biomass Energy and Bioprocess Technology ,CAS
Beclin-1 is involved in tongue sole Cynoglossus semilaevis immune defense against bacterial infection | |
Li, Xue-peng1,2; Chi, Heng1,2; Zhang, Jian1,2 | |
2018-06-01 | |
发表期刊 | FISH & SHELLFISH IMMUNOLOGY |
ISSN | 1050-4648 |
卷号 | 77页码:8-12 |
摘要 | In mammals, beclin-1 is a key player that regulates autophagic activity. In fish, the immune function of beclin-1 is essentially unknown. In this study, we analyzed the involvement of tongue sole (Cynoglossus semilaevis) beclin-1 (named CsBECN1) in antibacterial immunity. CsBECN1 is composed of 451 amino acid residues and shares 84.5-95.1% overall sequence identities with other teleost beclin-1. CsBECN1 possesses a typical Bcl-2 homology domain 3 and an Atg6 domain. Expression of CsBECN1 occurred in multiple tissues and was upregulated during bacterial infection. Knockdown of CsBECN1 significantly enhanced bacterial dissemination in the tissues of tongue sole, whereas overexpression of CsBECN1 significantly reduced bacterial dissemination. Taken together, these results indicate that CsBECN1 is required for the antibacterial immunity of tongue sole. |
文章类型 | Article |
关键词 | Beclin-1 Cynoglossus Semilaevis Gene Expression Immune Defense |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
DOI | 10.1016/j.fsi.2018.03.023 |
关键词[WOS] | MOLECULAR CHARACTERIZATION ; ADAPTIVE IMMUNITY ; AUTOPHAGY GENE ; UP-REGULATION ; PROTEIN ; EXPRESSION ; DEGRADATION ; INNATE ; TUMORIGENESIS ; MECHANISMS |
收录类别 | SCI |
语种 | 英语 |
WOS研究方向 | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
项目资助者 | National Natural Science Foundation of China(31330081 ; Key Laboratory of Mariculture (KLM), Ministry of Education, Ocean University of China ; Taishan Scholar Program of Shandong Province ; 31502197) |
WOS类目 | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
WOS记录号 | WOS:000432644300002 |
出版者 | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.qibebt.ac.cn/handle/337004/11440 |
专题 | 中国科学院青岛生物能源与过程研究所 |
通讯作者 | Zhang, Jian |
作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China |
推荐引用方式 GB/T 7714 | Li, Xue-peng,Chi, Heng,Zhang, Jian. Beclin-1 is involved in tongue sole Cynoglossus semilaevis immune defense against bacterial infection[J]. FISH & SHELLFISH IMMUNOLOGY,2018,77:8-12. |
APA | Li, Xue-peng,Chi, Heng,&Zhang, Jian.(2018).Beclin-1 is involved in tongue sole Cynoglossus semilaevis immune defense against bacterial infection.FISH & SHELLFISH IMMUNOLOGY,77,8-12. |
MLA | Li, Xue-peng,et al."Beclin-1 is involved in tongue sole Cynoglossus semilaevis immune defense against bacterial infection".FISH & SHELLFISH IMMUNOLOGY 77(2018):8-12. |
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