KMS Qingdao Institute of Biomass Energy and Bioprocess Technology ,CAS
Recent progress of the development of dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes mellitus | |
Li, Ning1,2,3,4; Wang, Li-Jun1,2,4; Jiang, Bo1,2,4; Li, Xiang-qian1,2,4; Guo, Chuan-long1,2,3,4; Guo, Shu-ju1,2,4; Shi, Da-Yong1,2,3,4 | |
2018-05-10 | |
发表期刊 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY |
ISSN | 0223-5234 |
卷号 | 151页码:145-157 |
摘要 | Diabetes is a fast growing chronic metabolic disorder around the world. Dipeptidyl peptidase-4 (DPP-4) is a new promising target during type 2 diabetes glycemic control. Thus, a number of potent DPP-4 inhibitors were developed and play a rapidly evolving role in the management of type 2 diabetes in recent years. This article reviews the development of synthetic and natural DPP-4 inhibitors from 2012 to 2017 and provides their physico-chemical properties, biological activities against DPP-4 and selectivity over dipeptidyl peptidase-8/9. Moreover, the glucose-lowering mechanisms and the active site of DPP-4 are also discussed. We also discuss strategies and structure-activity relationships for identifying potent DPP-4 inhibitors, which will provide useful information for developing potent DPP-4 drugs as type 2 diabtes treatments. (C) 2018 Elsevier Masson SAS. All rights reserved. |
文章类型 | Review |
关键词 | Dpp-4 Inhibitors Analogs Physico-chemical Properties Sars Type 2 Diabetes |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
DOI | 10.1016/j.ejmech.2018.03.041 |
关键词[WOS] | DPP-IV INHIBITORS ; GLUCAGON-LIKE PEPTIDE-1 ; BIOLOGICAL EVALUATION ; PHARMACOPHORE HYBRIDIZATION ; ANTIDIABETIC AGENTS ; CLINICAL CANDIDATE ; MOLECULAR DOCKING ; LEAD OPTIMIZATION ; HEALTHY-SUBJECTS ; POTENT |
收录类别 | SCI |
语种 | 英语 |
WOS研究方向 | Pharmacology & Pharmacy |
项目资助者 | National Natural Science Foundation of China(81773586 ; Shandong Provincial Natural Science Foundation for Distinguished Young Scholars(JQ201722) ; Key research and development project of Shandong province(2016GSF201193 ; Key Research Program of Frontier Sciences, CAS(QYZDB-SSW-DQC014) ; Project of Discovery, Evaluation and Transformation of Active Natural Compounds, Strategic Biological Resources Service Network Program of Chinese Academy of Sciences(ZSTH-026) ; National Science Foundation of China (NSFC)-Shandong Joint Fund(U1706213) ; National Program for Support of Top-notch Young Professionals ; Taishan scholar Youth Project of Shandong province and Qingdao Marine Biomedical Science and Technology Innovation Center project(2017-CXZ01-1-1 ; 81703354) ; 2016ZDJS07A13 ; 2017-CXZX01-3-9) ; 2016GSF115002 ; 2016GSF115009) |
WOS类目 | Chemistry, Medicinal |
WOS记录号 | WOS:000432640900011 |
出版者 | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.qibebt.ac.cn/handle/337004/11372 |
专题 | 中国科学院青岛生物能源与过程研究所 |
通讯作者 | Shi, Da-Yong |
作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Mega Sci, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Li, Ning,Wang, Li-Jun,Jiang, Bo,et al. Recent progress of the development of dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes mellitus[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2018,151:145-157. |
APA | Li, Ning.,Wang, Li-Jun.,Jiang, Bo.,Li, Xiang-qian.,Guo, Chuan-long.,...&Shi, Da-Yong.(2018).Recent progress of the development of dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes mellitus.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,151,145-157. |
MLA | Li, Ning,et al."Recent progress of the development of dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes mellitus".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 151(2018):145-157. |
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