Cow-to-mouse fecal transplantations suggest intestinal microbiome as one cause of mastitis
Ma, Chen1; Sun, Zheng3,4; Zeng, Benhua2; Huang, Shi3,4; Zhao, Jie1; Zhang, Yong1; Su, Xiaoquan3,4; Xu, Jian3,4; Wei, Hong5; Zhang, Heping1
Source PublicationMICROBIOME
AbstractBackgroundMastitis, which affects nearly all lactating mammals including human, is generally thought to be caused by local infection of the mammary glands. For treatment, antibiotics are commonly prescribed, which however are of concern in both treatment efficacy and neonate safety. Here, using bovine mastitis which is the most costly disease in the dairy industry as a model, we showed that intestinal microbiota alone can lead to mastitis.ResultsFecal microbiota transplantation (FMT) from mastitis, but not healthy cows, to germ-free (GF) mice resulted in mastitis symptoms in mammary gland and inflammations in serum, spleen, and colon. Probiotic intake in parallel with FMT from diseased cows led to relieved mastitis symptoms in mice, by shifting the murine intestinal microbiota to a state that is functionally distinct from either healthy or diseased microbiota yet structurally similar to the latter. Despite conservation in mastitis symptoms, diseased cows and mice shared few mastitis-associated bacterial organismal or functional markers, suggesting striking divergence in mastitis-associated intestinal microbiota among lactating mammals. Moreover, an amplification effect of disease-health distinction in both microbiota structure and function was apparent during the cow-to-mouse FMT.ConclusionsHence, dysbiosis of intestinal microbiota may be one cause of mastitis, and probiotics that restore intestinal microbiota function are an effective and safe strategy to treat mastitis.
KeywordMastitis Intestinal microbiota Fecal microbiota transplantation Germ-free mice Probiotics
Funding ProjectNational Natural Science Foundation of China[31400089] ; China Postdoctoral Science Foundation[2016LH00036]
WOS Research AreaMicrobiology
Funding OrganizationNational Natural Science Foundation of China ; China Postdoctoral Science Foundation
WOS SubjectMicrobiology
WOS IDWOS:000449968500002
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Document Type期刊论文
Corresponding AuthorXu, Jian; Wei, Hong; Zhang, Heping
Affiliation1.Inner Mongolia Agr Univ, Key Lab Dairy Biotechnol & Engn, Hohhot 010018, Peoples R China
2.Third Mil Med Univ, Dept Lab Anim Sci, Coll Basic Med Sci, Chongqing 400038, Peoples R China
3.Chinese Acad Sci, Qingdao Inst BioEnergy & Bioproc Technol, Single Cell Ctr, CAS Key Lab Biofuels, Qingdao 266101, Shandong, Peoples R China
4.Chinese Acad Sci, Shandong Key Lab Energy Genet, Qingdao Inst BioEnergy & Bioproc Technol, Qingdao 266101, Shandong, Peoples R China
5.Huazhong Agr Univ, Engn Technol Res Ctr Germ Free & Genome Editing A, Wuhan 430070, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Ma, Chen,Sun, Zheng,Zeng, Benhua,et al. Cow-to-mouse fecal transplantations suggest intestinal microbiome as one cause of mastitis[J]. MICROBIOME,2018,6:17.
APA Ma, Chen.,Sun, Zheng.,Zeng, Benhua.,Huang, Shi.,Zhao, Jie.,...&Zhang, Heping.(2018).Cow-to-mouse fecal transplantations suggest intestinal microbiome as one cause of mastitis.MICROBIOME,6,17.
MLA Ma, Chen,et al."Cow-to-mouse fecal transplantations suggest intestinal microbiome as one cause of mastitis".MICROBIOME 6(2018):17.
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