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Title:
A genomic view of the human-Bacteroides thetaiotaomicron symbiosis
Author: Xu Jian(徐健) ; Himrod J ; Deng S ; Carmichael LK ; Bjursell MK ; Chiang HC ; Hooper LV ; Gordon JI
Source: Science
Issued Date: 2003
Issue: 5615
Abstract:

The human gut is colonized with a vast community of indigenous microorganisms that help shape our biology. Here, we present the complete genome sequence of the Gram-negative anaerobe Bacteroides thetaiotaomicron, a dominant member of our normal distal intestinal microbiota. Its 4779-member proteome includes an elaborate apparatus for acquiring and hydrolyzing otherwise indigestible dietary polysaccharides and an associated environment-sensing system consisting of a large repertoire of extracytoplasmic function sigma factors and one- and two-component signal transduction systems. These and other expanded paralogous groups shed light on the molecular mechanisms underlying symbiotic host-bacterial relationships in our intestine.

English Abstract:

The human gut is colonized with a vast community of indigenous microorganisms that help shape our biology. Here, we present the complete genome sequence of the Gram-negative anaerobe Bacteroides thetaiotaomicron, a dominant member of our normal distal intestinal microbiota. Its 4779-member proteome includes an elaborate apparatus for acquiring and hydrolyzing otherwise indigestible dietary polysaccharides and an associated environment-sensing system consisting of a large repertoire of extracytoplasmic function sigma factors and one- and two-component signal transduction systems. These and other expanded paralogous groups shed light on the molecular mechanisms underlying symbiotic host-bacterial relationships in our intestine.

Language: 英语
Content Type: 期刊论文
URI: http://ir.qibebt.ac.cn/handle/337004/1079
Appears in Collections:单细胞中心_期刊论文

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Recommended Citation:
Xu J,Himrod J,Deng S,et al. A genomic view of the human-Bacteroides thetaiotaomicron symbiosis[J]. Science,2003(5615).
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文件名: A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.pdf
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