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A genomic view of the human-Bacteroides thetaiotaomicron symbiosis
Xu J; Himrod J; Deng S; Carmichael LK; Bjursell MK; Chiang HC; Hooper LV; Gordon JI
2003
发表期刊Science
期号5615
摘要

The human gut is colonized with a vast community of indigenous microorganisms that help shape our biology. Here, we present the complete genome sequence of the Gram-negative anaerobe Bacteroides thetaiotaomicron, a dominant member of our normal distal intestinal microbiota. Its 4779-member proteome includes an elaborate apparatus for acquiring and hydrolyzing otherwise indigestible dietary polysaccharides and an associated environment-sensing system consisting of a large repertoire of extracytoplasmic function sigma factors and one- and two-component signal transduction systems. These and other expanded paralogous groups shed light on the molecular mechanisms underlying symbiotic host-bacterial relationships in our intestine.

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The human gut is colonized with a vast community of indigenous microorganisms that help shape our biology. Here, we present the complete genome sequence of the Gram-negative anaerobe Bacteroides thetaiotaomicron, a dominant member of our normal distal intestinal microbiota. Its 4779-member proteome includes an elaborate apparatus for acquiring and hydrolyzing otherwise indigestible dietary polysaccharides and an associated environment-sensing system consisting of a large repertoire of extracytoplasmic function sigma factors and one- and two-component signal transduction systems. These and other expanded paralogous groups shed light on the molecular mechanisms underlying symbiotic host-bacterial relationships in our intestine.

语种英语
文献类型期刊论文
条目标识符http://ir.qibebt.ac.cn/handle/337004/1079
专题单细胞中心
推荐引用方式
GB/T 7714
Xu J,Himrod J,Deng S,et al. A genomic view of the human-Bacteroides thetaiotaomicron symbiosis[J]. Science,2003(5615).
APA Xu J.,Himrod J.,Deng S.,Carmichael LK.,Bjursell MK.,...&Gordon JI.(2003).A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.Science(5615).
MLA Xu J,et al."A genomic view of the human-Bacteroides thetaiotaomicron symbiosis".Science .5615(2003).
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