A genomic view of the human-Bacteroides thetaiotaomicron symbiosis | |
Xu J; Himrod J; Deng S; Carmichael LK; Bjursell MK; Chiang HC; Hooper LV; Gordon JI | |
2003 | |
发表期刊 | Science |
期号 | 5615 |
摘要 | The human gut is colonized with a vast community of indigenous microorganisms that help shape our biology. Here, we present the complete genome sequence of the Gram-negative anaerobe Bacteroides thetaiotaomicron, a dominant member of our normal distal intestinal microbiota. Its 4779-member proteome includes an elaborate apparatus for acquiring and hydrolyzing otherwise indigestible dietary polysaccharides and an associated environment-sensing system consisting of a large repertoire of extracytoplasmic function sigma factors and one- and two-component signal transduction systems. These and other expanded paralogous groups shed light on the molecular mechanisms underlying symbiotic host-bacterial relationships in our intestine. ;The human gut is colonized with a vast community of indigenous microorganisms that help shape our biology. Here, we present the complete genome sequence of the Gram-negative anaerobe Bacteroides thetaiotaomicron, a dominant member of our normal distal intestinal microbiota. Its 4779-member proteome includes an elaborate apparatus for acquiring and hydrolyzing otherwise indigestible dietary polysaccharides and an associated environment-sensing system consisting of a large repertoire of extracytoplasmic function sigma factors and one- and two-component signal transduction systems. These and other expanded paralogous groups shed light on the molecular mechanisms underlying symbiotic host-bacterial relationships in our intestine. |
语种 | 英语 |
文献类型 | 期刊论文 |
条目标识符 | http://ir.qibebt.ac.cn/handle/337004/1079 |
专题 | 单细胞中心组群 |
推荐引用方式 GB/T 7714 | Xu J,Himrod J,Deng S,et al. A genomic view of the human-Bacteroides thetaiotaomicron symbiosis[J]. Science,2003(5615). |
APA | Xu J.,Himrod J.,Deng S.,Carmichael LK.,Bjursell MK.,...&Gordon JI.(2003).A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.Science(5615). |
MLA | Xu J,et al."A genomic view of the human-Bacteroides thetaiotaomicron symbiosis".Science .5615(2003). |
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