QIBEBT-IR
Ruthenium(II)-enabled para-selective C-H difluoromethylation of anilides and their derivatives
Yuan, Chunchen1; Zhu, Lei2; Chen, Changpeng1; Chen, Xiaolan1; Yang, Yong3; Lan, Yu2; Zhao, Yingsheng1
2018-03-22
发表期刊NATURE COMMUNICATIONS
ISSN2041-1723
卷号9
摘要Transition-metal-catalyzed direct site-selective functionalization of arene C-H bonds has emerged as an innovative approach for building the core structure of pharmaceutical agents and other versatile complex compounds. However, para-selective C-H functionalization has seldom been explored, only a few examples, such as steric-hindered arenes, electron-rich arenes, and substrates with a directing group, have been reported to date. Here we describe the development of a ruthenium-enabled para-selective C-H difluoromethylation of anilides, indolines, and tetrahydroquinolines. This reaction tolerates various substituted arenes, affording para-difluoromethylation products in moderate to good yields. Results of a preliminary study of the mechanism indicate that chelation-assisted cycloruthenation might play a role in the selective activation of para-CAr-H bonds. Furthermore, this method provides a direct approach for the synthesis of fluorinated drug derivatives, which has important application for drug discovery and development.
文章类型Article
WOS标题词Science & Technology
DOI10.1038/s41467-018-03341-6
关键词[WOS]ORTHO-METALATION STRATEGY ; CARBON-HYDROGEN BONDS ; DIRECT ARYLATION ; BENZENE-DERIVATIVES ; FUNCTIONALIZATION ; ARENES ; ACTIVATION ; ALKYLATION ; FLUORINE ; BROMINATION
收录类别SCI
语种英语
WOS研究方向Science & Technology - Other Topics
项目资助者Natural Science Foundation of China(21772139 ; project of scientific and technologic infrastructure of Suzhou(SZS201708) ; PAPD Project ; 21572149 ; 21772020 ; 21372266)
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000428039500007
出版者NATURE PUBLISHING GROUP
引用统计
文献类型期刊论文
条目标识符http://ir.qibebt.ac.cn/handle/337004/10692
专题中国科学院青岛生物能源与过程研究所
通讯作者Lan, Yu; Zhao, Yingsheng
作者单位1.Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Peoples R China
2.Chongqing Univ, Sch Chem & Chem Engn, Chongqing 40030, Peoples R China
3.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao 266000, Peoples R China
推荐引用方式
GB/T 7714
Yuan, Chunchen,Zhu, Lei,Chen, Changpeng,et al. Ruthenium(II)-enabled para-selective C-H difluoromethylation of anilides and their derivatives[J]. NATURE COMMUNICATIONS,2018,9.
APA Yuan, Chunchen.,Zhu, Lei.,Chen, Changpeng.,Chen, Xiaolan.,Yang, Yong.,...&Zhao, Yingsheng.(2018).Ruthenium(II)-enabled para-selective C-H difluoromethylation of anilides and their derivatives.NATURE COMMUNICATIONS,9.
MLA Yuan, Chunchen,et al."Ruthenium(II)-enabled para-selective C-H difluoromethylation of anilides and their derivatives".NATURE COMMUNICATIONS 9(2018).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Yuan, Chunchen]的文章
[Zhu, Lei]的文章
[Chen, Changpeng]的文章
百度学术
百度学术中相似的文章
[Yuan, Chunchen]的文章
[Zhu, Lei]的文章
[Chen, Changpeng]的文章
必应学术
必应学术中相似的文章
[Yuan, Chunchen]的文章
[Zhu, Lei]的文章
[Chen, Changpeng]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。